Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   I6H78_RS05390 Genome accession   NZ_CP066059
Coordinates   1107621..1107746 (+) Length   41 a.a.
NCBI ID   WP_008282505.1    Uniprot ID   A0A139Q4L7
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1102621..1112746
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS05365 (I6H78_05365) dnaA 1103084..1104445 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  I6H78_RS05370 (I6H78_05370) spo0J 1104662..1105420 (-) 759 WP_198459028.1 ParB/RepB/Spo0J family partition protein Regulator
  I6H78_RS05375 (I6H78_05375) htrA 1105478..1106674 (-) 1197 WP_198459029.1 S1C family serine protease Regulator
  I6H78_RS05380 (I6H78_05380) rlmH 1106860..1107339 (+) 480 WP_198459030.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H78_RS05390 (I6H78_05390) comC/comC1 1107621..1107746 (+) 126 WP_008282505.1 competence-stimulating peptide ComC Regulator
  I6H78_RS05395 (I6H78_05395) comD 1107767..1109086 (+) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  I6H78_RS05400 (I6H78_05400) comE 1109083..1109835 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  I6H78_RS05415 (I6H78_05415) - 1110072..1110614 (-) 543 WP_033630549.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4957.73 Da        Isoelectric Point: 10.2767

>NTDB_id=516969 I6H78_RS05390 WP_008282505.1 1107621..1107746(+) (comC/comC1) [Streptococcus oralis strain FDAARGOS_1021]
MKNTVKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=516969 I6H78_RS05390 WP_008282505.1 1107621..1107746(+) (comC/comC1) [Streptococcus oralis strain FDAARGOS_1021]
ATGAAAAATACAGTAAAGTTGGAACAATTTAAAGAAGTAACAGAGGCAGAATTGCAGGAGATTCGGGGTGGAGATAAAAG
ACTACCTTACTTTTTTAAACATCTTTTTTCAAATAGGACAAAGTAG

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A139Q4L7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae G54

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae D39

53.659

100

0.537
  comC/comC1 Streptococcus pneumoniae Rx1

53.659

100

0.537
  comC Streptococcus mitis SK321

68.966

70.732

0.488
  comC/comC2 Streptococcus pneumoniae A66

58.621

70.732

0.415
  comC/comC2 Streptococcus pneumoniae TIGR4

58.621

70.732

0.415
  comC Streptococcus mitis NCTC 12261

55.556

65.854

0.366
  comC/blpC Streptococcus mutans UA159

44.118

82.927

0.366