Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGB/cglB   Type   Machinery gene
Locus tag   I6H78_RS04490 Genome accession   NZ_CP066059
Coordinates   932312..933328 (-) Length   338 a.a.
NCBI ID   WP_198460227.1    Uniprot ID   A0A7T4IUE1
Organism   Streptococcus oralis strain FDAARGOS_1021     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 927312..938328
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H78_RS04450 (I6H78_04450) - 927634..928824 (-) 1191 WP_198460190.1 acetate kinase -
  I6H78_RS04455 (I6H78_04455) comYH 928875..929828 (-) 954 WP_198460191.1 class I SAM-dependent methyltransferase Machinery gene
  I6H78_RS04460 (I6H78_04460) - 929887..930477 (-) 591 WP_198460192.1 class I SAM-dependent methyltransferase -
  I6H78_RS04465 (I6H78_04465) comGG/cglG 930510..930923 (-) 414 WP_000265643.1 competence type IV pilus minor pilin ComGG Machinery gene
  I6H78_RS04470 (I6H78_04470) comGF/cglF 930901..931362 (-) 462 WP_000250706.1 competence type IV pilus minor pilin ComGF Machinery gene
  I6H78_RS04475 (I6H78_04475) comGE/cglE 931325..931627 (-) 303 WP_000413374.1 competence type IV pilus minor pilin ComGE Machinery gene
  I6H78_RS04480 (I6H78_04480) comGD/cglD 931590..932024 (-) 435 WP_198460193.1 competence type IV pilus minor pilin ComGD Machinery gene
  I6H78_RS04485 (I6H78_04485) comGC/cglC 931987..932310 (-) 324 WP_000735798.1 competence type IV pilus major pilin ComGC Machinery gene
  I6H78_RS04490 (I6H78_04490) comGB/cglB 932312..933328 (-) 1017 WP_198460227.1 competence type IV pilus assembly protein ComGB Machinery gene
  I6H78_RS04495 (I6H78_04495) comGA/cglA/cilD 933276..934217 (-) 942 WP_198460194.1 competence type IV pilus ATPase ComGA Machinery gene
  I6H78_RS04500 (I6H78_04500) - 934280..934645 (-) 366 WP_000286396.1 DUF1033 family protein -
  I6H78_RS04505 (I6H78_04505) nagA 934798..935949 (-) 1152 WP_198460195.1 N-acetylglucosamine-6-phosphate deacetylase -
  I6H78_RS04510 (I6H78_04510) - 936090..937907 (-) 1818 WP_198460196.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 338 a.a.        Molecular weight: 38499.64 Da        Isoelectric Point: 9.5634

>NTDB_id=516962 I6H78_RS04490 WP_198460227.1 932312..933328(-) (comGB/cglB) [Streptococcus oralis strain FDAARGOS_1021]
MDISQVFRLKRKKLATAKQKKIITLFNNLFSSGFHLVEIISFLGRSALLEKDYVAQMHQGLAQGKSFSEMMDSLGFSSAI
VTQLSLAEVHGNLHLSLAKIEEYLENLAKVKKKLIEVATYPLILLGFLLLIMLGLRNYLLPQLDSSNIATQIISNLPQIF
LGLVLVCALSLLLALTFYKRSSKMRVFSMLARIPFLGIFVQTYLTAYYAREWGNMISQGMELTQIFQIMQEQGSQLFKEI
GQDLAQALQSGREFSQTIATYPFFKKELSLIIEYGEVKSKLGSELEIYAEKTWEAFFTRVNRTMNLVQPLVFIFVALIIV
LLYAAMLMPMYQNMEVNF

Nucleotide


Download         Length: 1017 bp        

>NTDB_id=516962 I6H78_RS04490 WP_198460227.1 932312..933328(-) (comGB/cglB) [Streptococcus oralis strain FDAARGOS_1021]
ATGGACATATCACAAGTCTTCAGGCTGAAACGGAAAAAATTAGCTACAGCTAAGCAGAAGAAAATCATCACCCTGTTTAA
CAACCTCTTTTCCAGTGGCTTTCATTTGGTGGAAATTATTTCTTTTTTGGGCAGAAGTGCCCTGCTGGAAAAGGACTATG
TGGCCCAGATGCACCAAGGCTTGGCTCAGGGGAAATCCTTTTCAGAGATGATGGACAGCTTGGGTTTTTCAAGTGCTATT
GTGACCCAATTATCTCTAGCTGAAGTTCATGGAAATCTCCACCTGAGTTTGGCAAAGATAGAAGAATATCTGGAAAATCT
GGCCAAGGTCAAGAAGAAGTTAATCGAAGTGGCGACCTATCCTTTGATTTTGCTGGGATTTCTCCTGCTAATTATGTTGG
GGCTCAGGAATTATTTGCTCCCCCAACTGGACAGTAGCAATATCGCCACCCAAATCATTAGCAATCTGCCACAAATTTTT
CTAGGACTAGTGCTGGTTTGCGCTCTATCTTTACTTTTAGCCCTCACTTTCTACAAAAGAAGTTCCAAGATGCGGGTCTT
CTCAATGTTAGCACGGATTCCCTTTCTAGGAATTTTTGTCCAGACCTATCTAACAGCCTATTACGCGCGTGAATGGGGCA
ATATGATTTCGCAGGGGATGGAGTTGACGCAGATTTTTCAAATCATGCAGGAACAAGGCTCTCAGCTCTTTAAAGAAATC
GGTCAAGATTTGGCTCAAGCCCTGCAAAGTGGCCGCGAATTTTCTCAAACCATAGCGACTTATCCTTTCTTTAAAAAGGA
GTTGAGTCTCATCATCGAGTATGGGGAAGTCAAGTCCAAGCTGGGGAGTGAGTTGGAAATCTATGCTGAGAAGACTTGGG
AAGCCTTTTTTACCCGAGTCAATCGTACCATGAATCTGGTACAGCCACTGGTTTTTATCTTTGTGGCCCTGATTATCGTT
TTACTTTATGCGGCAATGCTTATGCCCATGTATCAAAATATGGAGGTAAATTTTTAA

Domains

Predicted by InterproScan.

Type II secretion system (T2SS), protein F (T2SSF)

(209-329)

Type II secretion system (T2SS), protein F (T2SSF)

(24-141)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7T4IUE1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGB/cglB Streptococcus mitis SK321

92.308

100

0.923
  comGB/cglB Streptococcus mitis NCTC 12261

91.42

100

0.914
  comGB/cglB Streptococcus pneumoniae Rx1

89.645

100

0.896
  comGB/cglB Streptococcus pneumoniae D39

89.645

100

0.896
  comGB/cglB Streptococcus pneumoniae R6

89.645

100

0.896
  comGB/cglB Streptococcus pneumoniae TIGR4

89.645

100

0.896
  comYB Streptococcus gordonii str. Challis substr. CH1

73.214

99.408

0.728
  comYB Streptococcus mutans UA140

59.875

94.379

0.565
  comYB Streptococcus mutans UA159

59.875

94.379

0.565
  comGB Lactococcus lactis subsp. cremoris KW2

51.497

98.817

0.509