Detailed information NTG0516865

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6H72_RS06380
• Genome accession: NZ_CP066055
• Coordinates: 1271313..1272062 (+)
• Length: 249 a.a.
• NCBI ID: WP_003071650.1
• Uniprot ID: A0A380L579
• Organism: Streptococcus constellatus strain FDAARGOS_1015
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1266313..1277062

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H72_RS06350 (I6H72_06350)	spo0J	1266855..1267622 (-)	768	WP_198457704.1	ParB/RepB/Spo0J family partition protein	Regulator
I6H72_RS06355 (I6H72_06355)	htrA	1267677..1268867 (-)	1191	WP_198457705.1	S1C family serine protease	Regulator
I6H72_RS06360 (I6H72_06360)	rlmH	1269072..1269551 (+)	480	WP_006268880.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6H72_RS06370 (I6H72_06370)	-	1269834..1269980 (+)	147	WP_006268843.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
I6H72_RS06375 (I6H72_06375)	comD/comD1	1270000..1271313 (+)	1314	WP_232619560.1	GHKL domain-containing protein	Regulator
I6H72_RS06380 (I6H72_06380)	comE	1271313..1272062 (+)	750	WP_003071650.1	competence system response regulator transcription factor ComE	Regulator
I6H72_RS06395 (I6H72_06395)	-	1272383..1274959 (-)	2577	WP_198457706.1	YfhO family protein	-
I6H72_RS06400 (I6H72_06400)	-	1275033..1276655 (-)	1623	WP_006268876.1	ABC-F family ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29171.69 Da
• Isoelectric Point: 8.0453

>NTDB_id=516865 I6H72_RS06380 WP_003071650.1 1271313..1272062(+) (comE) [Streptococcus constellatus strain FDAARGOS_1015]
MKVLILEDEITHQVRMETTLAEIAKEMGIPIKVKITGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDAAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDEKTQRFFSPHKSYLVNIGNIKGYDKKTREIIFYEDHRCPITRMKIGKL
KSILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=516865 I6H72_RS06380 WP_003071650.1 1271313..1272062(+) (comE) [Streptococcus constellatus strain FDAARGOS_1015]
ATGAAAGTACTAATATTAGAAGATGAAATTACACATCAAGTTAGAATGGAAACAACATTGGCAGAAATAGCTAAGGAAAT
GGGGATTCCGATAAAAGTTAAAATAACTGGAAAAGTAAGAGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATTAAAGGTGAAGAAACAAAAGGGTTAGAAATAGCCAAATTTATACGGCATCACAATCCT
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACTATGACGTTTAAATATAAAGTATCTGCATTGGATTT
TGTTGATAAAAATTTGAATGATGCTGCTTTTAAAAAACATATAAAAGACAGTATTGAATATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTCCGTGGTGGCGAAGTTAGAATGCCTTTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTTGGTAAAAACTTTTTTAAAGAATTTTATGGTACGATTGCAGA
TATTCAGGAAAAAGACGAGAAAACACAGCGCTTCTTTTCACCTCATAAATCTTATCTAGTTAATATTGGGAATATTAAAG
GTTATGATAAAAAAACAAGAGAAATTATTTTTTATGAAGATCACCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTG
AAATCCATTTTAGAGGAGTCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: A0A380L579

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.837	98.394	0.707
comE	Streptococcus infantis strain Atu-4	71.02	98.394	0.699
comE	Streptococcus mitis SK321	71.02	98.394	0.699
comE	Streptococcus pneumoniae Rx1	70.612	98.394	0.695
comE	Streptococcus pneumoniae D39	70.612	98.394	0.695
comE	Streptococcus pneumoniae R6	70.612	98.394	0.695
comE	Streptococcus pneumoniae TIGR4	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	69.672	97.992	0.683
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	69.672	97.992	0.683
comE/blpR	Streptococcus mutans UA159	39.759	100	0.398
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361