Detailed information NTG0516470

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: I6H77_RS04210
• Genome accession: NZ_CP066021
• Coordinates: 856183..856935 (+)
• Length: 250 a.a.
• NCBI ID: WP_000866079.1
• Uniprot ID: A0A081R422
• Organism: Streptococcus oralis strain FDAARGOS_1020
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 851183..861935

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6H77_RS04180 (I6H77_04180)	spo0J	851762..852520 (-)	759	WP_000410357.1	ParB/RepB/Spo0J family partition protein	Regulator
I6H77_RS04185 (I6H77_04185)	htrA	852578..853774 (-)	1197	WP_000681805.1	S1C family serine protease	Regulator
I6H77_RS04190 (I6H77_04190)	rlmH	853960..854439 (+)	480	WP_000694221.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6H77_RS04200 (I6H77_04200)	comC/comC1	854721..854846 (+)	126	WP_002874960.1	competence-stimulating peptide ComC	Regulator
I6H77_RS04205 (I6H77_04205)	comD	854867..856186 (+)	1320	WP_000054555.1	competence system sensor histidine kinase ComD	Regulator
I6H77_RS04210 (I6H77_04210)	comE	856183..856935 (+)	753	WP_000866079.1	competence system response regulator transcription factor ComE	Regulator
I6H77_RS04225 (I6H77_04225)	-	857173..857715 (-)	543	WP_000665080.1	TetR/AcrR family transcriptional regulator	-
I6H77_RS04230 (I6H77_04230)	-	857843..860497 (+)	2655	WP_000472066.1	YhgE/Pip domain-containing protein	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29884.23 Da
• Isoelectric Point: 6.9755

>NTDB_id=516470 I6H77_RS04210 WP_000866079.1 856183..856935(+) (comE) [Streptococcus oralis strain FDAARGOS_1020]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=516470 I6H77_RS04210 WP_000866079.1 856183..856935(+) (comE) [Streptococcus oralis strain FDAARGOS_1020]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCGGAAGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACTTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGCCCGATTACCCGTTTGAAAGTTCGCAAACTA
AAAGATATTCTAGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081R422

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.6	100	0.956
comE	Streptococcus mitis SK321	94.8	100	0.948
comE	Streptococcus pneumoniae Rx1	94	100	0.94
comE	Streptococcus pneumoniae D39	94	100	0.94
comE	Streptococcus pneumoniae R6	94	100	0.94
comE	Streptococcus pneumoniae TIGR4	94	100	0.94
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	63.2	100	0.632
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.2	100	0.632
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4