Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6H77_RS04185 Genome accession   NZ_CP066021
Coordinates   852578..853774 (-) Length   398 a.a.
NCBI ID   WP_000681805.1    Uniprot ID   A0A7H9FDH2
Organism   Streptococcus oralis strain FDAARGOS_1020     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 847578..858774
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H77_RS04165 (I6H77_04165) - 848630..848824 (-) 195 WP_000285184.1 DUF951 domain-containing protein -
  I6H77_RS04170 (I6H77_04170) dnaN 848889..850025 (-) 1137 WP_000581146.1 DNA polymerase III subunit beta -
  I6H77_RS04175 (I6H77_04175) dnaA 850184..851545 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  I6H77_RS04180 (I6H77_04180) spo0J 851762..852520 (-) 759 WP_000410357.1 ParB/RepB/Spo0J family partition protein Regulator
  I6H77_RS04185 (I6H77_04185) htrA 852578..853774 (-) 1197 WP_000681805.1 S1C family serine protease Regulator
  I6H77_RS04190 (I6H77_04190) rlmH 853960..854439 (+) 480 WP_000694221.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H77_RS04200 (I6H77_04200) comC/comC1 854721..854846 (+) 126 WP_002874960.1 competence-stimulating peptide ComC Regulator
  I6H77_RS04205 (I6H77_04205) comD 854867..856186 (+) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  I6H77_RS04210 (I6H77_04210) comE 856183..856935 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  I6H77_RS04225 (I6H77_04225) - 857173..857715 (-) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 42014.80 Da        Isoelectric Point: 6.3580

>NTDB_id=516467 I6H77_RS04185 WP_000681805.1 852578..853774(-) (htrA) [Streptococcus oralis strain FDAARGOS_1020]
MKHLQKFYKKGVKVLVIILIGFLSGALGSFVTLQLYQKQGNQATNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SSSSRQSSVFNADDTNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDIRLADGTKVPGEIVGSDTFSDIAV
VKISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSG
GPLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESDGKVTRPALGIQMVNLSNVGASDLRKLNIPSGL
TSGVVVRSVQNNMPANGHLQKYDVITKVDDKEIASSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSSDLES

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=516467 I6H77_RS04185 WP_000681805.1 852578..853774(-) (htrA) [Streptococcus oralis strain FDAARGOS_1020]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTAGTAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTCGTAACATTACAACTTTATCAAAAACAAGGAAATCAAGCTACAAATAATAATTCTGGCACTGTCACTCAAA
CATCCTATAAGAATGAAAATTCAACCACTCAAGCAGTAAATAAAGTTAAGGATGCTGTTGTCTCAATCATTACTTATTCT
TCTTCTAGCAGTAGACAAAGTAGTGTATTTAATGCTGACGACACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGA
GGGATCAGGTGTTATCTATAAAAAGGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAA
AAGTTGATATACGCTTAGCTGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACCTTCTCTGATATTGCTGTC
GTTAAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGTCAACTTAGTGTTGGAGAAACAGCGAT
TGCTATCGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGGATTATTTCAAGTCTTAATCGGAATGTTT
CTCTAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACAGCCATTAACCCTGGTAACTCTGGT
GGTCCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGGACATCTGTAGA
AGGTCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTGATGGTAAAGTGACTCGTC
CTGCTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTGGCCTC
ACTTCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAA
AGTTGACGATAAAGAGATTGCTTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATCAAAG
TAACCTACTACCGTAATGGTAAGGAGGAAACAACCTCAATTAAACTAGATAAGAATTCTAGTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(229-393)

Trypsin-like peptidase domain (Trypsin_2)

(108-253)

PDZ domain (PDZ_2)

(294-389)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7H9FDH2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.668

100

0.837
  htrA Streptococcus pneumoniae Rx1

82.915

100

0.829
  htrA Streptococcus pneumoniae D39

82.915

100

0.829
  htrA Streptococcus pneumoniae R6

82.915

100

0.829
  htrA Streptococcus pneumoniae TIGR4

82.915

100

0.829
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.673
  htrA Streptococcus mutans UA159

54.315

98.995

0.538