Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   I6H77_RS04200 Genome accession   NZ_CP066021
Coordinates   854721..854846 (+) Length   41 a.a.
NCBI ID   WP_002874960.1    Uniprot ID   O33689
Organism   Streptococcus oralis strain FDAARGOS_1020     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 849721..859846
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6H77_RS04175 (I6H77_04175) dnaA 850184..851545 (-) 1362 WP_000660625.1 chromosomal replication initiator protein DnaA -
  I6H77_RS04180 (I6H77_04180) spo0J 851762..852520 (-) 759 WP_000410357.1 ParB/RepB/Spo0J family partition protein Regulator
  I6H77_RS04185 (I6H77_04185) htrA 852578..853774 (-) 1197 WP_000681805.1 S1C family serine protease Regulator
  I6H77_RS04190 (I6H77_04190) rlmH 853960..854439 (+) 480 WP_000694221.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6H77_RS04200 (I6H77_04200) comC/comC1 854721..854846 (+) 126 WP_002874960.1 competence-stimulating peptide ComC Regulator
  I6H77_RS04205 (I6H77_04205) comD 854867..856186 (+) 1320 WP_000054555.1 competence system sensor histidine kinase ComD Regulator
  I6H77_RS04210 (I6H77_04210) comE 856183..856935 (+) 753 WP_000866079.1 competence system response regulator transcription factor ComE Regulator
  I6H77_RS04225 (I6H77_04225) - 857173..857715 (-) 543 WP_000665080.1 TetR/AcrR family transcriptional regulator -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4987.71 Da        Isoelectric Point: 9.8680

>NTDB_id=516468 I6H77_RS04200 WP_002874960.1 854721..854846(+) (comC/comC1) [Streptococcus oralis strain FDAARGOS_1020]
MKNTEKLEQFKEVTEAELQEIRGGDKRLPYFFKHLFSNRTK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=516468 I6H77_RS04200 WP_002874960.1 854721..854846(+) (comC/comC1) [Streptococcus oralis strain FDAARGOS_1020]
ATGAAAAATACAGAAAAGTTGGAACAATTTAAAGAAGTAACAGAGGCAGAATTGCAGGAGATTCGAGGTGGAGATAAAAG
ACTACCTTACTTTTTTAAACATCTTTTTTCAAATAGGACAAAGTAG

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB O33689

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae G54

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae D39

51.22

100

0.512
  comC/comC1 Streptococcus pneumoniae Rx1

51.22

100

0.512
  comC Streptococcus mitis SK321

65.517

70.732

0.463
  comC/comC2 Streptococcus pneumoniae A66

55.172

70.732

0.39
  comC/comC2 Streptococcus pneumoniae TIGR4

55.172

70.732

0.39
  comC/blpC Streptococcus mutans UA159

44.118

82.927

0.366