Detailed information NTG0505747

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: I6L84_RS00245
• Genome accession: NZ_CP077224
• Coordinates: 52782..53549 (+)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain FDAARGOS 1454
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 47782..58549

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6L84_RS00215 (I6L84_00215)	spo0J	48276..49040 (-)	765	WP_045772585.1	ParB/RepB/Spo0J family partition protein	Regulator
I6L84_RS00220 (I6L84_00220)	htrA	49106..50299 (-)	1194	WP_060553296.1	S1C family serine protease	Regulator
I6L84_RS00225 (I6L84_00225)	rlmH	50493..50972 (+)	480	WP_060553297.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
I6L84_RS00235 (I6L84_00235)	comC/comC2	51259..51411 (+)	153	WP_008808033.1	bacteriocin	Regulator
I6L84_RS00240 (I6L84_00240)	comD/comD2	51427..52785 (+)	1359	WP_060553298.1	competence system sensor histidine kinase ComD	Regulator
I6L84_RS00245 (I6L84_00245)	comE/comE2	52782..53549 (+)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
I6L84_RS00260 (I6L84_00260)	ychF	53871..54986 (+)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
I6L84_RS00265 (I6L84_00265)	pth	55060..55629 (+)	570	WP_060553299.1	aminoacyl-tRNA hydrolase	-

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=505747 I6L84_RS00245 WP_008808031.1 52782..53549(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS 1454]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=505747 I6L84_RS00245 WP_008808031.1 52782..53549(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS 1454]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCCCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTTACGAGTCATTCAGAATTTGCGACCTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGACAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTTTATAT
ATTGAGACAACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTCTATGGAACAATAGCAGA
AATTCAGGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACACAAGTCATACCTATCTAATATTAGTAATATTAGTG
GATACGACAAAAAAACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATATTTA
AAAGAAATACTGAAAGCAAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361