Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6L84_RS00220 Genome accession   NZ_CP077224
Coordinates   49106..50299 (-) Length   397 a.a.
NCBI ID   WP_060553296.1    Uniprot ID   -
Organism   Streptococcus gordonii strain FDAARGOS 1454     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 44106..55299
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6L84_RS00195 (I6L84_00195) - 44688..45206 (+) 519 WP_020992856.1 YehR family protein -
  I6L84_RS00200 (I6L84_00200) - 45225..45428 (-) 204 WP_008808039.1 DUF951 domain-containing protein -
  I6L84_RS00205 (I6L84_00205) dnaN 45428..46564 (-) 1137 WP_008808038.1 DNA polymerase III subunit beta -
  I6L84_RS00210 (I6L84_00210) dnaA 46720..48072 (-) 1353 WP_008808037.1 chromosomal replication initiator protein DnaA -
  I6L84_RS00215 (I6L84_00215) spo0J 48276..49040 (-) 765 WP_045772585.1 ParB/RepB/Spo0J family partition protein Regulator
  I6L84_RS00220 (I6L84_00220) htrA 49106..50299 (-) 1194 WP_060553296.1 S1C family serine protease Regulator
  I6L84_RS00225 (I6L84_00225) rlmH 50493..50972 (+) 480 WP_060553297.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6L84_RS00235 (I6L84_00235) comC/comC2 51259..51411 (+) 153 WP_008808033.1 bacteriocin Regulator
  I6L84_RS00240 (I6L84_00240) comD/comD2 51427..52785 (+) 1359 WP_060553298.1 competence system sensor histidine kinase ComD Regulator
  I6L84_RS00245 (I6L84_00245) comE/comE2 52782..53549 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  I6L84_RS00260 (I6L84_00260) ychF 53871..54986 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42209.90 Da        Isoelectric Point: 5.4898

>NTDB_id=505744 I6L84_RS00220 WP_060553296.1 49106..50299(-) (htrA) [Streptococcus gordonii strain FDAARGOS 1454]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNIKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=505744 I6L84_RS00220 WP_060553296.1 49106..50299(-) (htrA) [Streptococcus gordonii strain FDAARGOS 1454]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGACGCGGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCAGATGCTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGTGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCTGATAAAGTAAAAAATGTAGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTGACTCAGGGGATTGTTTCCAGCCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAAACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAAGGTAT
GGGATTTGCAATACCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGAAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATATTAAGAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterProScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(292-387)

Peptidase family M50 (Peptidase_M50)

(236-391)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.992

100

0.99
  htrA Streptococcus mitis NCTC 12261

65.829

100

0.66
  htrA Streptococcus pneumoniae Rx1

65.909

99.748

0.657
  htrA Streptococcus pneumoniae D39

65.909

99.748

0.657
  htrA Streptococcus pneumoniae R6

65.909

99.748

0.657
  htrA Streptococcus pneumoniae TIGR4

65.909

99.748

0.657
  htrA Streptococcus mutans UA159

55.89

100

0.562