Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   HMPREF0833_RS08295 Genome accession   NC_015678
Coordinates   1782212..1783153 (+) Length   313 a.a.
NCBI ID   WP_013904485.1    Uniprot ID   F8DGS2
Organism   Streptococcus parasanguinis ATCC 15912     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1777212..1788153
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF0833_RS08275 (HMPREF0833_11651) - 1778155..1778943 (+) 789 WP_013904482.1 hypothetical protein -
  HMPREF0833_RS08280 (HMPREF0833_11652) - 1779086..1780396 (+) 1311 WP_013904483.1 glycosyltransferase -
  HMPREF0833_RS08285 (HMPREF0833_11653) - 1780405..1781508 (+) 1104 WP_013904484.1 glycosyl hydrolase family 8 -
  HMPREF0833_RS08290 (HMPREF0833_11654) - 1781734..1782126 (+) 393 WP_037617571.1 DUF1033 family protein -
  HMPREF0833_RS08295 (HMPREF0833_11655) comYA 1782212..1783153 (+) 942 WP_013904485.1 competence type IV pilus ATPase ComGA Machinery gene
  HMPREF0833_RS08300 (HMPREF0833_11656) comYB 1783086..1784117 (+) 1032 WP_115276785.1 competence type IV pilus assembly protein ComGB Machinery gene
  HMPREF0833_RS08305 (HMPREF0833_11657) comYC 1784114..1784431 (+) 318 WP_003019171.1 competence type IV pilus major pilin ComGC Machinery gene
  HMPREF0833_RS08310 (HMPREF0833_11658) comYD 1784421..1784825 (+) 405 WP_041818518.1 competence type IV pilus minor pilin ComGD Machinery gene
  HMPREF0833_RS08315 (HMPREF0833_11659) comGE 1784791..1785078 (+) 288 WP_013904488.1 competence type IV pilus minor pilin ComGE -
  HMPREF0833_RS08320 (HMPREF0833_11660) comGF/cglF 1785068..1785520 (+) 453 WP_003019060.1 competence type IV pilus minor pilin ComGF Machinery gene
  HMPREF0833_RS08325 (HMPREF0833_11661) comGG 1785477..1785944 (+) 468 WP_255309063.1 competence type IV pilus minor pilin ComGG -
  HMPREF0833_RS08330 (HMPREF0833_11662) comYH 1785975..1786928 (+) 954 WP_013904490.1 class I SAM-dependent methyltransferase Machinery gene

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35898.31 Da        Isoelectric Point: 6.7636

>NTDB_id=41398 HMPREF0833_RS08295 WP_013904485.1 1782212..1783153(+) (comYA) [Streptococcus parasanguinis ATCC 15912]
MVQEIAKKLIRMGKKEEAQDLYFIPRKEEYQVFMRVGDERRFVQSFPFEEMTAIISHFKFVAGMNVGEKRRSQLGSCDYP
LENGVVSIRLSTVGDYRGYESLVIRLLHDEERELRFWFDQLPDLKKKLAGRGLYLFAGPVGSGKTTLMHALAQERFADQQ
VMSIEDPVEIKQENMLQLQLNDQIGMTYDNLIKLSLRHRPDLLIIGEIRDKETARAVVRASLTGVTVFSTIHAKSVRGVY
ERLLELGVSEEELKIVLQGICYQRLIAGGGVVDFATENYQEHSASRWNQQMDLLAQSGYIQLAQAQAEKIIYR

Nucleotide


Download         Length: 942 bp        

>NTDB_id=41398 HMPREF0833_RS08295 WP_013904485.1 1782212..1783153(+) (comYA) [Streptococcus parasanguinis ATCC 15912]
ATGGTTCAAGAAATTGCAAAAAAATTGATCCGTATGGGGAAGAAGGAAGAAGCTCAGGATCTCTACTTCATTCCTCGGAA
GGAGGAGTATCAGGTTTTTATGAGGGTTGGAGATGAGAGGCGTTTTGTGCAATCCTTTCCTTTTGAGGAGATGACGGCTA
TTATCAGCCATTTTAAATTTGTAGCAGGGATGAATGTGGGAGAAAAAAGGCGCAGCCAGCTAGGATCGTGTGATTACCCT
TTGGAGAATGGAGTGGTTTCGATTCGCTTGTCGACGGTGGGGGATTATCGTGGCTATGAAAGCTTGGTCATTCGGCTTTT
GCATGATGAGGAACGCGAATTGCGGTTTTGGTTTGATCAGTTGCCAGACTTGAAGAAGAAATTGGCTGGTCGTGGGCTTT
ATCTCTTTGCGGGTCCCGTTGGTTCGGGAAAGACCACTCTCATGCACGCTCTGGCGCAAGAGCGCTTTGCAGATCAGCAA
GTCATGTCCATTGAAGATCCTGTCGAGATCAAGCAAGAGAATATGCTTCAGCTCCAGCTGAATGACCAGATCGGCATGAC
CTATGACAACCTGATCAAACTCTCCTTACGTCATCGACCGGATCTTCTCATTATTGGGGAGATCCGAGATAAGGAAACGG
CCCGTGCAGTTGTACGAGCTAGTTTGACAGGGGTCACCGTCTTCTCTACGATTCATGCCAAGAGCGTTAGAGGTGTTTAT
GAGCGCCTTTTAGAGCTTGGAGTGAGTGAGGAAGAACTCAAGATTGTTTTACAAGGTATTTGCTACCAACGATTAATTGC
AGGAGGAGGTGTTGTCGATTTTGCAACGGAAAACTACCAAGAGCACTCGGCCAGCCGCTGGAACCAACAAATGGATCTCT
TGGCTCAATCGGGATATATCCAGCTGGCTCAGGCGCAAGCCGAAAAAATTATCTACCGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(15-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F8DGS2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus gordonii str. Challis substr. CH1

73.871

99.042

0.732
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

71.474

99.681

0.712
  comGA/cglA/cilD Streptococcus pneumoniae D39

71.154

99.681

0.709
  comGA/cglA/cilD Streptococcus pneumoniae R6

71.154

99.681

0.709
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

71.154

99.681

0.709
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

71.154

99.681

0.709
  comYA Streptococcus mutans UA159

64.63

99.361

0.642
  comYA Streptococcus mutans UA140

64.63

99.361

0.642
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

61.935

99.042

0.613
  comGA Lactococcus lactis subsp. cremoris KW2

54.808

99.681

0.546
  comGA Latilactobacillus sakei subsp. sakei 23K

42.086

88.818

0.374

Multiple sequence alignment