Detailed information NTG0409416

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: GPZ88_RS03825
• Genome accession: NZ_CP046919
• Coordinates: 746715..747449 (-)
• Length: 244 a.a.
• NCBI ID: WP_133017806.1
• Uniprot ID: A0A6G8HZI3
• Organism: Streptococcus ruminicola strain CNU_G2
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 741715..752449

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPZ88_RS03800 (GPZ88_03770)	dusB	741777..742754 (+)	978	WP_166043478.1	tRNA dihydrouridine synthase DusB	-
GPZ88_RS03805 (GPZ88_03775)	-	742797..743564 (-)	768	WP_166043480.1	hypothetical protein	-
GPZ88_RS03810 (GPZ88_03780)	-	743571..744443 (-)	873	WP_166043482.1	ABC transporter ATP-binding protein	-
GPZ88_RS03815 (GPZ88_03785)	-	744471..745217 (-)	747	WP_039697807.1	hypothetical protein	-
GPZ88_RS03820 (GPZ88_03790)	-	745353..746711 (-)	1359	WP_166043484.1	sensor histidine kinase	-
GPZ88_RS03825 (GPZ88_03795)	comE/blpR	746715..747449 (-)	735	WP_133017806.1	response regulator transcription factor	Regulator
GPZ88_RS03830 (GPZ88_03800)	-	747459..747791 (-)	333	WP_166043486.1	LytR/AlgR family response regulator transcription factor	-
GPZ88_RS03835 (GPZ88_03805)	-	747977..748336 (+)	360	WP_166043488.1	hypothetical protein	-
GPZ88_RS03840 (GPZ88_03810)	clpC	748393..750834 (-)	2442	WP_166043490.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
GPZ88_RS03845 (GPZ88_03815)	-	750831..751292 (-)	462	WP_166043492.1	CtsR family transcriptional regulator	-
GPZ88_RS03850 (GPZ88_03820)	-	751550..752014 (+)	465	WP_074603058.1	COG2426 family protein	-

Sequence

Protein

• Length: 244 a.a.
• Molecular weight: 28409.33 Da
• Isoelectric Point: 5.4115

>NTDB_id=409416 GPZ88_RS03825 WP_133017806.1 746715..747449(-) (comE/blpR) [Streptococcus ruminicola strain CNU_G2]
MLNIFVLEDDFFQQSRLEQAINRCMKENQLKYRQLEIFGKPQQLLEAIKEQGNHQFFFLDIEIKGEEKKGMEIAREIRAK
DPNAVIVFVTTHSEFMPVTYKYRVAALDFIDKGLNEEEFQEAVSSVLVYAFENVDTTVASDAFVFKNEHSHVQVPFSDIL
YFETSSTIHKVILTTKTGHMEFYGKVSDIAKADERLYQSHRAYVVNPENVTKIDRTNHIVYFEGDESCFVSRLKLKGLIE
RVEK

Nucleotide

• Length: 735 bp

>NTDB_id=409416 GPZ88_RS03825 WP_133017806.1 746715..747449(-) (comE/blpR) [Streptococcus ruminicola strain CNU_G2]
ATGCTAAATATCTTTGTGTTAGAGGATGATTTTTTCCAACAATCACGTTTGGAACAAGCTATTAATCGTTGTATGAAAGA
AAATCAACTGAAATACCGTCAGTTGGAGATTTTTGGGAAGCCTCAACAGCTTTTGGAAGCTATCAAGGAACAAGGGAATC
ATCAATTTTTTTTCTTAGATATTGAAATTAAAGGAGAAGAGAAAAAAGGAATGGAGATTGCGCGTGAAATTCGTGCTAAA
GACCCTAATGCAGTGATTGTTTTTGTGACGACGCACTCTGAATTTATGCCAGTAACTTATAAGTACCGTGTAGCGGCACT
TGATTTTATTGATAAAGGGCTAAATGAAGAGGAGTTTCAAGAGGCAGTATCATCTGTTTTAGTATATGCTTTTGAAAATG
TCGATACCACAGTAGCAAGTGATGCCTTTGTCTTTAAAAACGAGCATTCACACGTTCAAGTTCCTTTTTCGGATATTTTG
TACTTCGAGACATCATCAACAATTCACAAAGTTATTTTAACCACAAAAACAGGGCATATGGAATTTTATGGCAAGGTTTC
AGATATCGCAAAAGCAGACGAACGTCTTTACCAAAGTCACCGTGCCTATGTCGTTAATCCAGAAAATGTTACCAAAATCG
ATCGCACCAACCATATCGTCTACTTCGAAGGCGATGAATCGTGCTTTGTGTCACGCCTGAAACTAAAAGGATTAATCGAA
AGAGTGGAGAAATAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (152-241)

• Response regulator receiver domain (Response_reg) (4-123)

3D structure

• AlphaFold DB: A0A6G8HZI3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	57.741	97.951	0.566
comE/comE1	Streptococcus equinus JB1	47.28	97.951	0.463
comE/comE2	Streptococcus equinus JB1	39.918	99.59	0.398
comE	Streptococcus infantis strain Atu-4	37.6	100	0.385
comE	Streptococcus mitis SK321	37.6	100	0.385
comE	Streptococcus pneumoniae Rx1	37.6	100	0.385
comE	Streptococcus pneumoniae D39	37.6	100	0.385
comE	Streptococcus pneumoniae R6	37.6	100	0.385
comE	Streptococcus pneumoniae TIGR4	37.6	100	0.385
comE	Streptococcus mitis NCTC 12261	37.6	100	0.385
comE/comE2	Streptococcus gordonii strain NCTC7865	36.885	100	0.369
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	36.885	100	0.369