Detailed information NTG0409417

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: GPZ88_RS03840
• Genome accession: NZ_CP046919
• Coordinates: 748393..750834 (-)
• Length: 813 a.a.
• NCBI ID: WP_166043490.1
• Uniprot ID: A0A6G8HZH2
• Organism: Streptococcus ruminicola strain CNU_G2
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 743393..755834

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GPZ88_RS03810 (GPZ88_03780)	-	743571..744443 (-)	873	WP_166043482.1	ABC transporter ATP-binding protein	-
GPZ88_RS03815 (GPZ88_03785)	-	744471..745217 (-)	747	WP_039697807.1	hypothetical protein	-
GPZ88_RS03820 (GPZ88_03790)	-	745353..746711 (-)	1359	WP_166043484.1	sensor histidine kinase	-
GPZ88_RS03825 (GPZ88_03795)	comE/blpR	746715..747449 (-)	735	WP_133017806.1	response regulator transcription factor	Regulator
GPZ88_RS03830 (GPZ88_03800)	-	747459..747791 (-)	333	WP_166043486.1	LytR/AlgR family response regulator transcription factor	-
GPZ88_RS03835 (GPZ88_03805)	-	747977..748336 (+)	360	WP_166043488.1	hypothetical protein	-
GPZ88_RS03840 (GPZ88_03810)	clpC	748393..750834 (-)	2442	WP_166043490.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
GPZ88_RS03845 (GPZ88_03815)	-	750831..751292 (-)	462	WP_166043492.1	CtsR family transcriptional regulator	-
GPZ88_RS03850 (GPZ88_03820)	-	751550..752014 (+)	465	WP_074603058.1	COG2426 family protein	-
GPZ88_RS03855 (GPZ88_03825)	tsf	752114..753151 (-)	1038	WP_166043494.1	translation elongation factor Ts	-
GPZ88_RS03860 (GPZ88_03830)	rpsB	753258..754025 (-)	768	WP_021143273.1	30S ribosomal protein S2	-
GPZ88_RS03870	-	755201..755353 (+)	153	WP_166043496.1	hypothetical protein	-

Sequence

Protein

• Length: 813 a.a.
• Molecular weight: 90080.53 Da
• Isoelectric Point: 6.4774

>NTDB_id=409417 GPZ88_RS03840 WP_166043490.1 748393..750834(-) (clpC) [Streptococcus ruminicola strain CNU_G2]
MSEYSMKMQEVFSIAQYQAARFESPYLESWHVLLAMVAVHDSVAGLTFAEYQNKIAYEEYEAAAVLALGKSPLADVKNVQ
FLEQSKALKDVLTFAESICKVTGSTEVGTEHVLYAMLLNLDLFATRLLEVAGFKNKEDGDSARLLDLRKSLSRNAGFTKE
KIKAIHDLRKPKKATMGGAFSEMMKPQSTAGELSDFTRDLTELARQGKLEPVIGREKEVSRMVQVLSRKTKNNPVLVGEA
GVGKTALAYGLAQRIVNGEIPYELQDMRVLELDMMSVVAGTRFRGDFEERMNQIISDIEADGHIILFIDEVHTIMGSGSG
IDSTLDAANILKPALARGTLHMVGATTQEEYQKHIEKDAALSRRFAKITIEEPSVEDAYQILLGLKKSYETFHNVTISDQ
AVLTAVKAAHRYLTSKNLPDSAIDLLDEASATVQGLVKKETPSDLTPADQAILEGDFKKATKLLKASRKAVTRKPTAVTE
DDIMATLSRLSGIPVEKMTQADSKKYLTLEKELHKRVIGQDAAISAISRAIRRNQAGIRTGKRPIGSFMFLGPTGVGKTE
LAKALAELLFDDESTLIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQV
LDDGVLTDSRGRKVDFSNTIIIMTSNLGATALRDDKTVGFGARDMAHDYDAMQKRIMEELKKTYRPEFINRIDEKVVFHH
LTQENMRDVVKIMVKPLIATLAEKDITLKFQPSALKYLAEAGYDPEMGARPLRRTLQDKVEDKLSELILSGELASGNTLK
IGVSKGQLKFDIA

Nucleotide

• Length: 2442 bp

>NTDB_id=409417 GPZ88_RS03840 WP_166043490.1 748393..750834(-) (clpC) [Streptococcus ruminicola strain CNU_G2]
ATGAGTGAATATTCAATGAAAATGCAGGAGGTTTTCAGTATCGCCCAGTACCAAGCGGCGCGATTTGAAAGCCCATATTT
AGAAAGTTGGCATGTGCTTTTAGCCATGGTAGCTGTTCATGATTCAGTGGCAGGGTTAACATTTGCTGAATACCAAAATA
AGATTGCTTACGAAGAGTACGAAGCGGCAGCTGTTTTGGCGCTCGGGAAATCACCTTTGGCAGATGTTAAAAATGTGCAG
TTCTTAGAACAATCTAAAGCCCTAAAAGACGTCTTAACTTTTGCTGAGTCAATTTGCAAAGTGACTGGAAGCACTGAAGT
CGGAACAGAGCATGTCCTTTATGCTATGTTGTTGAATCTCGATTTGTTTGCGACACGTCTTTTGGAAGTTGCTGGATTTA
AAAATAAAGAAGATGGTGATTCAGCACGCTTGCTTGATTTGCGTAAATCATTGTCACGTAATGCTGGATTTACTAAAGAA
AAAATCAAAGCTATTCACGATCTTCGCAAACCCAAAAAAGCTACAATGGGCGGAGCTTTCTCAGAAATGATGAAACCTCA
GTCAACTGCGGGAGAATTATCAGACTTCACTCGTGATTTAACTGAATTAGCTCGTCAAGGAAAACTTGAGCCAGTTATCG
GACGTGAAAAAGAAGTCTCTCGCATGGTTCAAGTACTTAGCCGTAAGACTAAAAATAATCCTGTCTTGGTCGGTGAAGCT
GGTGTTGGTAAAACAGCTCTTGCTTATGGTTTGGCACAACGTATTGTTAATGGTGAAATTCCTTATGAGCTTCAAGACAT
GCGTGTCTTAGAGCTTGATATGATGAGTGTTGTTGCGGGAACTCGTTTCCGTGGTGATTTCGAAGAACGCATGAACCAAA
TCATCTCAGACATTGAAGCTGATGGTCATATTATTTTATTCATCGATGAAGTGCACACTATTATGGGATCTGGTTCTGGA
ATTGATAGTACTTTAGATGCTGCTAATATCTTAAAACCTGCTCTTGCACGTGGTACGCTTCACATGGTTGGTGCGACAAC
TCAAGAAGAATATCAAAAACATATCGAAAAAGATGCAGCTCTTTCACGTCGTTTTGCGAAAATTACGATTGAAGAACCAA
GTGTTGAAGATGCTTATCAAATTTTACTTGGGCTTAAGAAATCTTACGAAACTTTCCATAATGTGACGATTTCTGATCAA
GCTGTGTTGACGGCTGTTAAAGCTGCACACCGTTATTTGACAAGTAAAAATCTACCAGACTCAGCTATTGATTTGCTTGA
TGAAGCTAGTGCAACCGTTCAAGGTTTGGTGAAAAAAGAAACACCTTCTGACTTAACTCCAGCTGACCAAGCTATCTTAG
AAGGTGATTTCAAAAAAGCTACAAAATTGCTAAAAGCATCACGTAAAGCTGTGACACGTAAGCCAACAGCTGTGACAGAA
GATGACATTATGGCAACTCTTAGTCGCTTGTCAGGTATTCCAGTTGAAAAAATGACGCAAGCCGACAGCAAGAAATATTT
GACGCTTGAAAAAGAATTGCACAAACGTGTGATTGGTCAAGATGCTGCTATTTCAGCGATTAGCCGAGCAATCCGTCGTA
ATCAAGCAGGTATCCGTACAGGAAAACGTCCAATTGGGTCATTCATGTTCTTGGGACCTACTGGTGTTGGTAAGACTGAA
TTAGCTAAAGCTTTGGCTGAACTTCTCTTTGATGATGAATCAACACTTATCCGCTTTGACATGTCTGAATACATGGAAAA
ATTTGCGGCTAGTCGTCTTAACGGAGCTCCTCCAGGATACGTTGGTTATGAAGAAGGTGGCGAATTGACTGAAAAAGTTC
GTAACAAACCTTATTCAGTCCTTCTTTTCGATGAAGTTGAAAAAGCTCATCCAGATATTTTCAACGTCCTTCTTCAAGTT
TTGGATGATGGTGTGTTGACAGATAGTCGTGGTCGTAAAGTTGATTTCTCAAATACGATTATTATCATGACGTCAAACCT
TGGTGCGACAGCTCTTCGTGATGATAAAACTGTTGGATTTGGTGCGCGTGATATGGCTCATGATTATGATGCTATGCAAA
AACGTATCATGGAAGAGCTTAAGAAAACTTATCGTCCAGAATTCATCAACCGTATTGATGAAAAGGTTGTCTTCCACCAC
TTAACACAAGAAAATATGCGTGACGTGGTTAAAATCATGGTTAAACCATTGATTGCAACCTTAGCTGAAAAAGATATTAC
GCTTAAATTCCAACCATCAGCGCTTAAATACCTTGCTGAAGCTGGATACGACCCAGAAATGGGTGCTCGTCCTCTTCGCC
GTACCCTACAAGATAAAGTCGAAGATAAATTATCAGAACTTATTCTATCAGGCGAATTAGCAAGTGGAAATACCCTTAAA
ATTGGTGTTTCAAAAGGACAACTTAAATTTGACATTGCTTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (721-800)

• ATPase family associated with various cellular activities (AAA) (AAA) (235-367)

• AAA domain (Cdc48 subfamily) (AAA_2) (543-714)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (95-134)

• AAA lid domain (AAA_lid_9) (374-456)

3D structure

• AlphaFold DB: A0A6G8HZH2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus mutans UA159	77.217	99.877	0.771
clpC	Streptococcus thermophilus LMG 18311	74.233	100	0.744
clpC	Streptococcus thermophilus LMD-9	74.233	100	0.744
clpC	Streptococcus pneumoniae TIGR4	67.734	99.877	0.677
clpC	Streptococcus pneumoniae Rx1	67.734	99.877	0.677
clpC	Streptococcus pneumoniae D39	67.734	99.877	0.677
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	49.94	100	0.512
clpC	Bacillus subtilis subsp. subtilis str. 168	43.803	100	0.448
clpE	Streptococcus pneumoniae TIGR4	46.106	78.967	0.364
clpE	Streptococcus pneumoniae Rx1	46.106	78.967	0.364
clpE	Streptococcus pneumoniae D39	46.106	78.967	0.364
clpE	Streptococcus pneumoniae R6	46.106	78.967	0.364