Detailed information NTG0405073

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: GOM46_RS05060
• Genome accession: NZ_CP046525
• Coordinates: 1011320..1011961 (-)
• Length: 213 a.a.
• NCBI ID: WP_006150927.1
• Uniprot ID: F5W1F2
• Organism: Streptococcus infantis strain SO
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1006320..1016961

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GOM46_RS05040 (GOM46_05030)	-	1006961..1007161 (-)	201	WP_001054554.1	F0F1 ATP synthase subunit C	-
GOM46_RS05045 (GOM46_05035)	-	1007392..1007703 (-)	312	WP_025170042.1	CHY zinc finger protein	-
GOM46_RS05050 (GOM46_05040)	-	1007717..1009003 (-)	1287	WP_006150948.1	peptidase U32 family protein	-
GOM46_RS05055 (GOM46_05045)	comEC/celB	1009126..1011336 (-)	2211	WP_235083305.1	ComEC/Rec2 family competence protein	Machinery gene
GOM46_RS05060 (GOM46_05050)	comEA/celA/cilE	1011320..1011961 (-)	642	WP_006150927.1	helix-hairpin-helix domain-containing protein	Machinery gene
GOM46_RS05065 (GOM46_05055)	-	1012027..1012596 (-)	570	WP_006150922.1	GNAT family N-acetyltransferase	-
GOM46_RS05070 (GOM46_05060)	ald	1012762..1013874 (+)	1113	WP_006150941.1	alanine dehydrogenase	-
GOM46_RS05075 (GOM46_05065)	-	1013921..1014907 (-)	987	WP_025170041.1	PhoH family protein	-
GOM46_RS05080 (GOM46_05070)	-	1014992..1015207 (-)	216	WP_001232087.1	YozE family protein	-
GOM46_RS05085 (GOM46_05075)	cvfB	1015216..1016070 (-)	855	WP_025170040.1	RNA-binding virulence regulatory protein CvfB	-
GOM46_RS05090 (GOM46_05080)	frr	1016131..1016688 (-)	558	WP_006150944.1	ribosome recycling factor	-

Sequence

Protein

• Length: 213 a.a.
• Molecular weight: 23266.38 Da
• Isoelectric Point: 4.9302

>NTDB_id=405073 GOM46_RS05060 WP_006150927.1 1011320..1011961(-) (comEA/celA/cilE) [Streptococcus infantis strain SO]
MEELIEKIKEYKIIVICVSLGLILGGFFLLKPVAQTPAKESNLQTEFTTVSKDSTDEKEDGNQKEEVVEQDLITVDVKGA
VKSPGIYDLPVGSRINDAVQKAGGLTDNADSKSINLAQRISDEALVYVPTKEEATSQEMPSSASNNKENKKVNLNKASVE
ELKQVKGLGAKRAQDIIDHRESNGKFKSVDDLKKVSGIGAKTIEKLKEYVTVD

Nucleotide

• Length: 642 bp

>NTDB_id=405073 GOM46_RS05060 WP_006150927.1 1011320..1011961(-) (comEA/celA/cilE) [Streptococcus infantis strain SO]
ATGGAAGAACTTATTGAGAAAATAAAAGAATATAAAATCATCGTCATCTGTGTTAGTTTGGGTTTGATCTTGGGTGGATT
TTTCCTCTTAAAACCAGTCGCTCAAACACCTGCTAAAGAAAGTAATTTGCAGACAGAATTTACAACTGTTTCGAAGGATT
CGACGGATGAAAAGGAGGATGGGAATCAGAAGGAAGAAGTGGTAGAGCAAGATCTAATTACTGTCGATGTCAAAGGGGCT
GTTAAATCGCCAGGGATTTACGATTTGCCAGTTGGAAGTCGTATCAATGATGCTGTTCAAAAAGCTGGTGGACTGACAGA
TAATGCTGATAGTAAGTCTATCAATCTTGCCCAGAGAATTAGTGACGAAGCGCTTGTCTATGTTCCAACTAAGGAAGAAG
CTACCAGTCAAGAAATGCCATCAAGTGCTTCTAACAACAAGGAAAATAAGAAAGTCAATCTCAATAAAGCCAGTGTAGAG
GAACTTAAACAAGTCAAAGGTTTAGGTGCGAAACGTGCGCAAGATATTATTGACCATCGTGAGTCCAACGGTAAGTTCAA
GTCAGTTGATGATCTTAAAAAGGTTTCTGGTATTGGTGCAAAAACGATAGAAAAGTTAAAAGAGTATGTTACAGTGGATT
AG

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (149-211)

• SLBB domain (SLBB) (75-124)

3D structure

• AlphaFold DB: F5W1F2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	77.778	100	0.789
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	77.315	100	0.784
comEA/celA/cilE	Streptococcus pneumoniae Rx1	76.389	100	0.775
comEA/celA/cilE	Streptococcus pneumoniae D39	76.389	100	0.775
comEA/celA/cilE	Streptococcus pneumoniae R6	76.389	100	0.775
comEA/celA/cilE	Streptococcus mitis SK321	75.926	100	0.77
comEA	Lactococcus lactis subsp. cremoris KW2	40.625	100	0.427
comEA	Streptococcus thermophilus LMD-9	37.179	100	0.408
comEA	Staphylococcus aureus MW2	34.842	100	0.362
comEA	Staphylococcus aureus N315	35.16	100	0.362