Detailed information NTG0405023

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: GOM47_RS09605
• Genome accession: NZ_CP046524
• Coordinates: 1938687..1939439 (-)
• Length: 250 a.a.
• NCBI ID: WP_084948177.1
• Uniprot ID: A0A7X9MHL4
• Organism: Streptococcus oralis strain SOT
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1933687..1944439

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GOM47_RS09585 (GOM47_09585)	-	1935121..1937775 (-)	2655	WP_235080666.1	YhgE/Pip domain-containing protein	-
GOM47_RS09590 (GOM47_09590)	-	1937904..1938446 (+)	543	WP_235080667.1	TetR/AcrR family transcriptional regulator	-
GOM47_RS09605 (GOM47_09605)	comE	1938687..1939439 (-)	753	WP_084948177.1	competence system response regulator transcription factor ComE	Regulator
GOM47_RS09610 (GOM47_09610)	comD	1939436..1940773 (-)	1338	WP_235080668.1	competence system sensor histidine kinase ComD	Regulator
GOM47_RS09615 (GOM47_09615)	comC/comC1	1940785..1940913 (-)	129	WP_081102474.1	competence-stimulating peptide ComC	Regulator
GOM47_RS09625 (GOM47_09625)	rlmH	1941194..1941673 (-)	480	WP_235080669.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
GOM47_RS09630 (GOM47_09630)	htrA	1941857..1943047 (+)	1191	WP_235080670.1	S1C family serine protease	Regulator
GOM47_RS09635 (GOM47_09635)	spo0J	1943105..1943863 (+)	759	WP_235080671.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29934.28 Da
• Isoelectric Point: 6.9820

>NTDB_id=405023 GOM47_RS09605 WP_084948177.1 1938687..1939439(-) (comE) [Streptococcus oralis strain SOT]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLINIGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
RDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=405023 GOM47_RS09605 WP_084948177.1 1938687..1939439(-) (comE) [Streptococcus oralis strain SOT]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCTGAGGAATC
AAATATTCCTATTTCTTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCTTAGATATCGATATTCACGGGATTGAGAAAAAGGGATTTGAAGTGGCACAGTTTATCCGCCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACTTACAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTTAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTATAACTATAAGGGAAATGATTTGAAAATCCCTTACCATGATATTTTGTAT
ATCGAAACTACAGGTGTTTCTCATAAACTGCGAATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGAACCATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTCTCCTCATAAATCTTTCCTAATCAATATTGGAAATGTTAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCCATTACCCGTTTGAAAGTCCGCAAACTG
AGAGATATTCTGGAGAAAAAATCTAAAAAGTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A7X9MHL4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96	100	0.96
comE	Streptococcus mitis SK321	95.2	100	0.952
comE	Streptococcus pneumoniae Rx1	94.4	100	0.944
comE	Streptococcus pneumoniae D39	94.4	100	0.944
comE	Streptococcus pneumoniae R6	94.4	100	0.944
comE	Streptococcus pneumoniae TIGR4	94.4	100	0.944
comE	Streptococcus infantis strain Atu-4	93.6	100	0.936
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4