Detailed information NTG0404952

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: GOM48_RS09710
• Genome accession: NZ_CP046523
• Coordinates: 1933460..1934212 (-)
• Length: 250 a.a.
• NCBI ID: WP_235097585.1
• Uniprot ID: -
• Organism: Streptococcus oralis strain SOD
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1928460..1939212

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GOM48_RS09690 (GOM48_09625)	-	1929907..1932549 (-)	2643	WP_235097582.1	YhgE/Pip domain-containing protein	-
GOM48_RS09695 (GOM48_09630)	-	1932678..1933220 (+)	543	WP_235097583.1	TetR/AcrR family transcriptional regulator	-
GOM48_RS09710 (GOM48_09645)	comE	1933460..1934212 (-)	753	WP_235097585.1	competence system response regulator transcription factor ComE	Regulator
GOM48_RS09715 (GOM48_09650)	comD	1934209..1935528 (-)	1320	WP_235097586.1	competence system sensor histidine kinase ComD	Regulator
GOM48_RS09720 (GOM48_09655)	comC	1935541..1935663 (-)	123	WP_235097589.1	competence-stimulating peptide ComC	Regulator
GOM48_RS09730 (GOM48_09665)	rlmH	1935946..1936425 (-)	480	WP_235097591.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
GOM48_RS09735 (GOM48_09670)	htrA	1936610..1937800 (+)	1191	WP_235097593.1	S1C family serine protease	Regulator
GOM48_RS09740 (GOM48_09675)	spo0J	1937858..1938616 (+)	759	WP_235097595.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29948.31 Da
• Isoelectric Point: 6.9820

>NTDB_id=404952 GOM48_RS09710 WP_235097585.1 1933460..1934212(-) (comE) [Streptococcus oralis strain SOD]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLINIGNVREIDRKNLEIVFYEDHRCPITRLKVRKL
RDILEKKSKK

Nucleotide

• Length: 753 bp

>NTDB_id=404952 GOM48_RS09710 WP_235097585.1 1933460..1934212(-) (comE) [Streptococcus oralis strain SOD]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAGCATCAAGTGAGACTAGAGAGAATATTGAATGAAATCTCGGAGGAATC
AAATATTCCTATTTCTTACAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCACGGAATTGAGAAAAAGGGCTTTGAAGTGGCACAGTTTATCCGTCATCACAATCCT
TATGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACTTTAACTTATAAATACCAGGTATCAGCTCTAGATTT
TGTAGACAAAGACATCAATGATGAATTGTTCAAAAAACGTATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAGGGAAATGATTTGAAAATCCCTTACCATGATATTTTGTAT
ATCGAAACAACAGGTGTTTCTCATAAGTTGCGGATTATTGGTAAGAATTTTGCCAAAGAGTTCTATGGAACAATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTCTCCTCATAAATCTTTCCTAATCAATATTGGAAATGTTAGAG
AAATTGATCGAAAGAATCTAGAAATTGTCTTTTATGAAGATCATCGCTGTCCCATCACTCGTTTGAAAGTTCGCAAACTG
AGAGATATTCTGGAGAAAAAATCTAAAAAGTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	96.4	100	0.964
comE	Streptococcus mitis SK321	95.6	100	0.956
comE	Streptococcus pneumoniae Rx1	94.8	100	0.948
comE	Streptococcus pneumoniae D39	94.8	100	0.948
comE	Streptococcus pneumoniae R6	94.8	100	0.948
comE	Streptococcus pneumoniae TIGR4	94.8	100	0.948
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	63.6	100	0.636
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	63.6	100	0.636
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4