Detailed information NTG0403298

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: GL186_RS10835
• Genome accession: NZ_CP046358
• Coordinates: 2116783..2117535 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 566
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2111783..2122535

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GL186_RS11430	-	2114216..2115819 (-)	1604	Protein_2113	YhgE/Pip family protein	-
GL186_RS10820 (GL186_11010)	-	2115998..2116540 (+)	543	WP_001158269.1	TetR/AcrR family transcriptional regulator	-
GL186_RS10835 (GL186_11025)	comE	2116783..2117535 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
GL186_RS10840 (GL186_11030)	comD/comD2	2117532..2118857 (-)	1326	WP_024477997.1	competence system sensor histidine kinase ComD	Regulator
GL186_RS10845 (GL186_11035)	comC/comC2	2118878..2119003 (-)	126	WP_000799694.1	competence-stimulating peptide ComC	Regulator
GL186_RS10855 (GL186_11045)	rlmH	2119285..2119764 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
GL186_RS10860 (GL186_11050)	htrA	2119947..2121128 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
GL186_RS10865 (GL186_11055)	spo0J	2121186..2121944 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=403298 GL186_RS10835 WP_000866065.1 2116783..2117535(-) (comE) [Streptococcus pneumoniae strain 566]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=403298 GL186_RS10835 WP_000866065.1 2116783..2117535(-) (comE) [Streptococcus pneumoniae strain 566]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATTGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408