Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   GL186_RS10860 Genome accession   NZ_CP046358
Coordinates   2119947..2121128 (+) Length   393 a.a.
NCBI ID   WP_000681598.1    Uniprot ID   A0A0B7M448
Organism   Streptococcus pneumoniae strain 566     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 2114947..2126128
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GL186_RS10820 (GL186_11010) - 2115998..2116540 (+) 543 WP_001158269.1 TetR/AcrR family transcriptional regulator -
  GL186_RS10835 (GL186_11025) comE 2116783..2117535 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  GL186_RS10840 (GL186_11030) comD/comD2 2117532..2118857 (-) 1326 WP_024477997.1 competence system sensor histidine kinase ComD Regulator
  GL186_RS10845 (GL186_11035) comC/comC2 2118878..2119003 (-) 126 WP_000799694.1 competence-stimulating peptide ComC Regulator
  GL186_RS10855 (GL186_11045) rlmH 2119285..2119764 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  GL186_RS10860 (GL186_11050) htrA 2119947..2121128 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  GL186_RS10865 (GL186_11055) spo0J 2121186..2121944 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  GL186_RS10870 (GL186_11060) dnaA 2122157..2123518 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41827.69 Da        Isoelectric Point: 6.8902

>NTDB_id=403301 GL186_RS10860 WP_000681598.1 2119947..2121128(+) (htrA) [Streptococcus pneumoniae strain 566]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=403301 GL186_RS10860 WP_000681598.1 2119947..2121128(+) (htrA) [Streptococcus pneumoniae strain 566]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAATAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7M448

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

99.746

100

0.997
  htrA Streptococcus pneumoniae D39

99.746

100

0.997
  htrA Streptococcus pneumoniae R6

99.746

100

0.997
  htrA Streptococcus pneumoniae TIGR4

99.746

100

0.997
  htrA Streptococcus mitis NCTC 12261

97.455

100

0.975
  htrA Streptococcus gordonii str. Challis substr. CH1

66.667

100

0.672
  htrA Streptococcus mutans UA159

54.822

100

0.55

Multiple sequence alignment