Detailed information NTG0402703

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: FOB91_RS06715
• Genome accession: NZ_CP046328
• Coordinates: 1364366..1365133 (-)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain FDAARGOS_683
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1359366..1370133

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FOB91_RS06695 (FOB91_06695)	pth	1362286..1362855 (-)	570	WP_012131076.1	aminoacyl-tRNA hydrolase	-
FOB91_RS06700 (FOB91_06700)	ychF	1362929..1364044 (-)	1116	WP_012131077.1	redox-regulated ATPase YchF	-
FOB91_RS06715 (FOB91_06715)	comE/comE2	1364366..1365133 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
FOB91_RS06720 (FOB91_06720)	comD/comD1	1365130..1366491 (-)	1362	WP_012131078.1	competence system sensor histidine kinase ComD	Regulator
FOB91_RS06725 (FOB91_06725)	comC/comC1	1366507..1366659 (-)	153	WP_012131079.1	bacteriocin	Regulator
FOB91_RS06735 (FOB91_06735)	rlmH	1366945..1367424 (-)	480	WP_012131080.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FOB91_RS06740 (FOB91_06740)	htrA	1367618..1368811 (+)	1194	WP_012131081.1	S1C family serine protease	Regulator
FOB91_RS06745 (FOB91_06745)	spo0J	1368877..1369641 (+)	765	WP_012131082.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=402703 FOB91_RS06715 WP_008808031.1 1364366..1365133(-) (comE/comE2) [Streptococcus gordonii strain FDAARGOS_683]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=402703 FOB91_RS06715 WP_008808031.1 1364366..1365133(-) (comE/comE2) [Streptococcus gordonii strain FDAARGOS_683]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TTTATTTCTTAGATATAGATATTAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTCTATAT
ATTGAGACGACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTTTATGGGACAATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACATAAGTCATACCTATCTAATATTAGCAACATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTATATTATGATGGTCATCGTTCACCGATTTCTCGATTACGTGTCAGATACTTG
AAAGAAATACTGAAAGCCAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361