Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   FOB91_RS06740 Genome accession   NZ_CP046328
Coordinates   1367618..1368811 (+) Length   397 a.a.
NCBI ID   WP_012131081.1    Uniprot ID   A0AB34SBT8
Organism   Streptococcus gordonii strain FDAARGOS_683     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1362618..1373811
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FOB91_RS06700 (FOB91_06700) ychF 1362929..1364044 (-) 1116 WP_012131077.1 redox-regulated ATPase YchF -
  FOB91_RS06715 (FOB91_06715) comE/comE2 1364366..1365133 (-) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  FOB91_RS06720 (FOB91_06720) comD/comD1 1365130..1366491 (-) 1362 WP_012131078.1 competence system sensor histidine kinase ComD Regulator
  FOB91_RS06725 (FOB91_06725) comC/comC1 1366507..1366659 (-) 153 WP_012131079.1 bacteriocin Regulator
  FOB91_RS06735 (FOB91_06735) rlmH 1366945..1367424 (-) 480 WP_012131080.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  FOB91_RS06740 (FOB91_06740) htrA 1367618..1368811 (+) 1194 WP_012131081.1 S1C family serine protease Regulator
  FOB91_RS06745 (FOB91_06745) spo0J 1368877..1369641 (+) 765 WP_012131082.1 ParB/RepB/Spo0J family partition protein Regulator
  FOB91_RS06750 (FOB91_06750) dnaA 1369844..1371196 (+) 1353 WP_011999558.1 chromosomal replication initiator protein DnaA -
  FOB91_RS06755 (FOB91_06755) dnaN 1371352..1372488 (+) 1137 WP_011999559.1 DNA polymerase III subunit beta -
  FOB91_RS06760 (FOB91_06760) - 1372488..1372691 (+) 204 WP_008808039.1 DUF951 domain-containing protein -
  FOB91_RS06765 (FOB91_06765) - 1372701..1373219 (-) 519 WP_011999560.1 YehR family protein -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42183.77 Da        Isoelectric Point: 4.9802

>NTDB_id=402706 FOB91_RS06740 WP_012131081.1 1367618..1368811(+) (htrA) [Streptococcus gordonii strain FDAARGOS_683]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSATNNNQKTATTVTTSYKNSNSTTEAVDKVKDAVVSVITYS
ESNSDAIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPDNVKN
GVVVRSTQTGMPADGKLEKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=402706 FOB91_RS06740 WP_012131081.1 1367618..1368811(+) (htrA) [Streptococcus gordonii strain FDAARGOS_683]
ATGAAAAACTCTTCAAATTTCTTTAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCACAAATAATAATCAGAAAACAGCGACTACAGTAACAA
CATCCTATAAAAATAGTAATTCTACAACAGAGGCTGTTGATAAAGTAAAAGATGCGGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCAGATGCTATTTTCGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAGGATTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAAGTTAAAAATGTGGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTGACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAGACAATTGCTACTCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGACAATGTTAAAAAT
GGTGTCGTTGTTCGTTCAACACAAACTGGAATGCCTGCTGATGGTAAGTTAGAAAAATATGATGTGATTACAAAAATTGA
TGATACAGAAATATCATCTGCTAGCGATATTCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGCTCTGAATAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(292-387)

Peptidase family M50 (Peptidase_M50)

(236-391)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

100

100

1
  htrA Streptococcus mitis NCTC 12261

66.332

100

0.665
  htrA Streptococcus pneumoniae Rx1

66.414

99.748

0.662
  htrA Streptococcus pneumoniae D39

66.414

99.748

0.662
  htrA Streptococcus pneumoniae R6

66.414

99.748

0.662
  htrA Streptococcus pneumoniae TIGR4

66.414

99.748

0.662
  htrA Streptococcus mutans UA159

56.14

100

0.564

Multiple sequence alignment