Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   G8B37_RS03490 Genome accession   NZ_CP049695
Coordinates   678935..679597 (+) Length   220 a.a.
NCBI ID   WP_002995626.1    Uniprot ID   A0A0H2UV22
Organism   Streptococcus pyogenes strain ABC76     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 673935..684597
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  G8B37_RS03470 (G8B37_03490) - 674808..676809 (+) 2002 Protein_626 KUP/HAK/KT family potassium transporter -
  G8B37_RS03475 (G8B37_03495) - 676833..677111 (-) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  G8B37_RS03480 (G8B37_03500) - 677101..677877 (-) 777 WP_010922438.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  G8B37_RS03485 (G8B37_03505) - 677995..678735 (+) 741 WP_021299345.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
  G8B37_RS03490 (G8B37_03510) comEA/celA/cilE 678935..679597 (+) 663 WP_002995626.1 ComEA family DNA-binding protein Machinery gene
  G8B37_RS03495 (G8B37_03515) comEC/celB 679578..681821 (+) 2244 WP_011528768.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  G8B37_RS03500 (G8B37_03520) holA 681892..682932 (+) 1041 WP_011017949.1 DNA polymerase III subunit delta -
  G8B37_RS03505 (G8B37_03525) sodA 683029..683634 (+) 606 WP_002983977.1 superoxide dismutase SodA -
  G8B37_RS03510 (G8B37_03530) - 683801..683947 (+) 147 WP_011528767.1 hypothetical protein -

Sequence

Protein


Download         Length: 220 a.a.        Molecular weight: 24623.45 Da        Isoelectric Point: 6.7451

>NTDB_id=374978 G8B37_RS03490 WP_002995626.1 678935..679597(+) (comEA/celA/cilE) [Streptococcus pyogenes strain ABC76]
MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQSKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLK
GAVQKEGVYKLTASSRVRDVIELAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIFLD

Nucleotide


Download         Length: 663 bp        

>NTDB_id=374978 G8B37_RS03490 WP_002995626.1 678935..679597(+) (comEA/celA/cilE) [Streptococcus pyogenes strain ABC76]
ATGTTAGACGAATTATTAATTAAAGGAAAATCGTTTTTGAGAGAGCGGTATTTTCTGCCATACCTAATTAGTCTTTTATT
AGGACTTTTTCTAATACTAAGCTTCAGTTTTTTGTTCTGGGGAAATAGGCAGAGCAAGGCAGCCGTTCCTGCTTTGAGAG
AAATATCGCCTGTGAAACAGCAGGTTAGTGAAGAAAAAAAGGAAATTCAAGAAGATAACAGTATTTTAGTGGATTTAAAA
GGCGCCGTACAAAAAGAGGGAGTTTATAAGCTAACTGCTAGCAGTCGTGTGCGAGATGTCATTGAACTAGCTGGAGGCCT
AACTTCAGAAGCTGATAAACATGCTATTAATTTTGCAGAAAAACTAACTGATGAGCAAGTTGTTTATGTACCTAAACAAG
GAGAAGAGATTTCTGTGCTACCAAGATCATTAGTTTCTGGTAAAAAAGAAACTGCCAGCAAGGATCAGTCAAAGGTTCAT
ATTAATAAGGCCAGCTTAGAAGAACTACAACATATCCCAGGTATTGGTGCTAAAAGAGCTCAGGATATTATTGATATGAG
AGATAAGTTAGGTGGTTTTAAAGCGTTAGAAGATCTCCGTCAGGTTTCGGGGATTGGCGAAAAAACGCTCGAGAAATTAA
AAGATGACATTTTCTTGGACTAA

Domains

Predicted by InterProScan.

SLBB domain (SLBB)

(77-130)

Helix-hairpin-helix motif (HHH_3)

(156-217)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UV22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

42.995

94.091

0.405

Multiple sequence alignment