Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   FPL13_RS00690 Genome accession   NZ_CP041968
Coordinates   128295..129236 (+) Length   313 a.a.
NCBI ID   WP_049513218.1    Uniprot ID   A0A7L8W3A5
Organism   Streptococcus sp. KS 6     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 123295..134236
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  FPL13_RS00665 (FPL13_00685) - 124489..125172 (+) 684 WP_049513227.1 COG3942 and LysM peptidoglycan-binding domain-containing protein -
  FPL13_RS00670 (FPL13_00690) - 125322..125852 (+) 531 WP_049513225.1 FUSC family protein -
  FPL13_RS00675 (FPL13_00695) - 125929..126288 (+) 360 WP_049513223.1 MerR family transcriptional regulator -
  FPL13_RS00680 (FPL13_00700) glnA 126326..127672 (+) 1347 WP_049513221.1 type I glutamate--ammonia ligase -
  FPL13_RS00685 (FPL13_00705) - 127860..128225 (+) 366 WP_049507022.1 DUF1033 family protein -
  FPL13_RS00690 (FPL13_00710) comYA 128295..129236 (+) 942 WP_049513218.1 competence type IV pilus ATPase ComGA Machinery gene
  FPL13_RS00695 (FPL13_00715) comGB 129178..130199 (+) 1022 Protein_137 competence type IV pilus assembly protein ComGB -
  FPL13_RS00700 (FPL13_00720) comYC 130196..130513 (+) 318 WP_003028473.1 competence type IV pilus major pilin ComGC Machinery gene
  FPL13_RS00705 (FPL13_00725) comYD 130473..130901 (+) 429 WP_049507639.1 competence type IV pilus minor pilin ComGD Machinery gene
  FPL13_RS00710 (FPL13_00730) comGE/cglE 130873..131166 (+) 294 WP_049513214.1 competence type IV pilus minor pilin ComGE Machinery gene
  FPL13_RS00715 (FPL13_00735) comGF/cglF 131150..131587 (+) 438 WP_049513212.1 competence type IV pilus minor pilin ComGF Machinery gene
  FPL13_RS00720 (FPL13_00740) comGG 131568..131894 (+) 327 WP_264340993.1 competence type IV pilus minor pilin ComGG -
  FPL13_RS00725 (FPL13_00745) - 131966..132918 (+) 953 Protein_143 class I SAM-dependent methyltransferase -
  FPL13_RS00730 (FPL13_00750) - 132965..134164 (+) 1200 WP_049513208.1 acetate kinase -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35754.98 Da        Isoelectric Point: 6.0540

>NTDB_id=374977 FPL13_RS00690 WP_049513218.1 128295..129236(+) (comYA) [Streptococcus sp. KS 6]
MVQNIAQAIICQAKEEQAQDIYVVPKENMYELYMRIGDERRFIQQYAFEEMAAVISHFKFTAGMNVGEKRRSQLGSCDYQ
YGDKKTSLRLSTVGDYRGYESLVIRLLHDEESELKFWFAQIPELKECFKQRGLYLFSGPVGSGKTTLMHQLAQERFAGQQ
IMSIEDPVEIKQPSMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDGETARAVVRASLTGVTVFSTIHAKSVRGVY
ERLLELGVTEADLKIVLQGICYQRLIAKGGIVDFVSEKYQEHEPIDWNRQIDQLHAAGHINLEQAEAEKIIHS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=374977 FPL13_RS00690 WP_049513218.1 128295..129236(+) (comYA) [Streptococcus sp. KS 6]
ATGGTTCAAAATATTGCACAGGCTATTATTTGCCAAGCTAAGGAAGAACAGGCACAGGATATTTACGTTGTTCCAAAGGA
GAATATGTATGAGCTATACATGCGAATTGGCGATGAACGGCGTTTTATCCAACAGTATGCATTTGAAGAGATGGCAGCAG
TAATTAGTCATTTCAAGTTTACCGCTGGAATGAATGTCGGCGAAAAACGTAGAAGCCAGTTAGGATCTTGTGATTATCAA
TATGGTGATAAGAAAACGTCATTACGACTGTCAACAGTAGGGGATTATCGTGGATATGAAAGTCTGGTGATTCGTTTATT
ACATGATGAAGAGTCAGAGTTGAAGTTTTGGTTTGCTCAAATCCCAGAGTTAAAAGAATGCTTCAAACAACGAGGGCTTT
ATCTTTTTTCGGGACCAGTAGGGAGTGGAAAAACGACTCTCATGCACCAACTTGCCCAAGAGCGCTTTGCTGGTCAACAA
ATCATGTCCATTGAAGACCCTGTTGAAATCAAGCAGCCTAGCATGTTACAGTTGCAATTGAATGAAGCGATTGGTTTGAC
TTATGAAAATTTGATTAAACTTTCTCTACGGCACCGACCGGATTTGCTAATCATCGGAGAAATTCGAGATGGGGAGACAG
CACGGGCAGTTGTTCGAGCTAGCTTAACGGGAGTGACTGTTTTTTCAACTATTCATGCTAAAAGCGTACGAGGTGTCTAT
GAACGGTTGTTGGAATTGGGAGTGACAGAAGCCGATCTGAAAATTGTCTTGCAAGGGATTTGTTACCAACGTTTAATTGC
AAAAGGAGGAATAGTGGATTTTGTCAGTGAAAAGTATCAAGAACACGAGCCCATCGACTGGAATAGGCAGATTGATCAGC
TTCATGCAGCAGGACATATCAATCTTGAACAAGCAGAAGCGGAAAAAATTATCCACAGTTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A7L8W3A5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus gordonii str. Challis substr. CH1

82.903

99.042

0.821
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

75.399

100

0.754
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

75.08

100

0.751
  comGA/cglA/cilD Streptococcus pneumoniae D39

75.08

100

0.751
  comGA/cglA/cilD Streptococcus pneumoniae R6

75.08

100

0.751
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

75.08

100

0.751
  comYA Streptococcus mutans UA159

64.63

99.361

0.642
  comYA Streptococcus mutans UA140

64.63

99.361

0.642
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.258

99.042

0.617
  comGA Lactococcus lactis subsp. cremoris KW2

54.019

99.361

0.537
  comGA Latilactobacillus sakei subsp. sakei 23K

43.629

82.748

0.361

Multiple sequence alignment