Detailed information NTG0352636

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: ES276_RS06545
• Genome accession: NZ_CP038252
• Coordinates: 1273840..1274490 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387346.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain TVO_1901936
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1268840..1279490

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ES276_RS06515 (ES276_06975)	-	1269347..1269562 (+)	216	WP_001232082.1	YozE family protein	-
ES276_RS06520 (ES276_06980)	-	1269648..1270616 (+)	969	WP_238092963.1	PhoH family protein	-
ES276_RS06525 (ES276_06990)	-	1270809..1271309 (+)	501	WP_000566985.1	GNAT family N-acetyltransferase	-
ES276_RS06530 (ES276_06995)	-	1271312..1271638 (+)	327	Protein_1279	TfoX/Sxy family protein	-
ES276_RS06535 (ES276_07000)	ald	1271939..1273026 (-)	1088	Protein_1280	alanine dehydrogenase	-
ES276_RS06540 (ES276_07005)	-	1273203..1273772 (+)	570	WP_000443745.1	GNAT family N-acetyltransferase	-
ES276_RS06545 (ES276_07010)	comEA/celA/cilE	1273840..1274490 (+)	651	WP_000387346.1	helix-hairpin-helix domain-containing protein	Machinery gene
ES276_RS06550 (ES276_07015)	comEC/celB	1274474..1276714 (+)	2241	WP_000942416.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ES276_RS10990 (ES276_07020)	-	1276863..1277080 (+)	218	Protein_1284	hypothetical protein	-
ES276_RS06555 (ES276_07025)	-	1277113..1277700 (+)	588	WP_000939883.1	ATP-binding cassette domain-containing protein	-
ES276_RS06560 (ES276_07030)	-	1277704..1278885 (+)	1182	WP_000655941.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23109.37 Da
• Isoelectric Point: 6.0661

>NTDB_id=352636 ES276_RS06545 WP_000387346.1 1273840..1274490(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901936]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDSSTGKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=352636 ES276_RS06545 WP_000387346.1 1273840..1274490(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain TVO_1901936]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGGAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	98.611	100	0.986
comEA/celA/cilE	Streptococcus pneumoniae Rx1	96.759	100	0.968
comEA/celA/cilE	Streptococcus pneumoniae D39	96.759	100	0.968
comEA/celA/cilE	Streptococcus pneumoniae R6	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	92.593	100	0.926
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Latilactobacillus sakei subsp. sakei 23K	34.335	100	0.37
comEA	Bacillus subtilis subsp. subtilis str. 168	41.053	87.963	0.361