Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   MGAS15252_RS07945 Genome accession   NC_017040
Coordinates   1655451..1656722 (-) Length   423 a.a.
NCBI ID   WP_014407933.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS15252     
Function   facilitate localization of RecA (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1650451..1661722
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS15252_RS07920 (MGAS15252_1640) - 1652420..1652725 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  MGAS15252_RS07925 (MGAS15252_1641) ruvX 1652737..1653156 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  MGAS15252_RS07930 (MGAS15252_1642) - 1653153..1653422 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  MGAS15252_RS07935 (MGAS15252_1643) spx 1653537..1653935 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  MGAS15252_RS07940 (MGAS15252_1644) recA 1654226..1655362 (-) 1137 WP_014407932.1 recombinase RecA -
  MGAS15252_RS07945 (MGAS15252_1645) cinA 1655451..1656722 (-) 1272 WP_014407933.1 competence/damage-inducible protein A Machinery gene
  MGAS15252_RS07950 (MGAS15252_1646) - 1656791..1657351 (-) 561 WP_010922755.1 DNA-3-methyladenine glycosylase I -
  MGAS15252_RS07955 (MGAS15252_1647) ruvA 1657361..1657957 (-) 597 WP_002992186.1 Holliday junction branch migration protein RuvA Machinery gene
  MGAS15252_RS07960 (MGAS15252_1648) - 1657959..1659179 (-) 1221 WP_014407934.1 MDR family MFS transporter -
  MGAS15252_RS07965 (MGAS15252_1649) hexB 1659190..1661172 (-) 1983 WP_014407935.1 DNA mismatch repair endonuclease MutL Machinery gene

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45980.70 Da        Isoelectric Point: 4.8322

>NTDB_id=35090 MGAS15252_RS07945 WP_014407933.1 1655451..1656722(-) (cinA) [Streptococcus pyogenes MGAS15252]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDEQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFSGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=35090 MGAS15252_RS07945 WP_014407933.1 1655451..1656722(-) (cinA) [Streptococcus pyogenes MGAS15252]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTAATTTTATGTGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATGAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTTCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACGGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterProScan.

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Competence-damaged protein (CinA)

(263-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.74

100

0.697
  cinA Streptococcus mitis SK321

70.264

98.582

0.693
  cinA Streptococcus mitis NCTC 12261

69.784

98.582

0.688
  cinA Streptococcus pneumoniae TIGR4

68.825

98.582

0.678
  cinA Streptococcus pneumoniae R36A

68.825

98.582

0.678
  cinA Streptococcus pneumoniae Rx1

68.825

98.582

0.678
  cinA Streptococcus pneumoniae R6

68.825

98.582

0.678
  cinA Streptococcus pneumoniae D39

68.585

98.582

0.676
  cinA Streptococcus suis isolate S10

53.125

98.345

0.522
  cinA Bacillus subtilis subsp. subtilis str. 168

46.89

98.818

0.463

Multiple sequence alignment