Detailed information    

insolico Bioinformatically predicted

Overview

Name   comGA/cglA/cilD   Type   Machinery gene
Locus tag   EQH22_RS09820 Genome accession   NZ_CP035258
Coordinates   1911694..1912635 (-) Length   313 a.a.
NCBI ID   WP_000249555.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain TVO_1901927     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1906694..1917635
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  EQH22_RS09780 (EQH22_10275) comYH 1907181..1908134 (-) 954 WP_000345127.1 class I SAM-dependent methyltransferase Machinery gene
  EQH22_RS09785 (EQH22_10280) - 1908195..1908789 (-) 595 Protein_1934 class I SAM-dependent methyltransferase -
  EQH22_RS09790 (EQH22_10285) comGG/cglG 1908892..1909338 (-) 447 WP_001811371.1 competence type IV pilus minor pilin ComGG Machinery gene
  EQH22_RS09795 (EQH22_10290) comGF/cglF 1909316..1909777 (-) 462 WP_000250539.1 competence type IV pilus minor pilin ComGF Machinery gene
  EQH22_RS09800 (EQH22_10295) comGE/cglE 1909740..1910042 (-) 303 WP_000413382.1 competence type IV pilus minor pilin ComGE Machinery gene
  EQH22_RS09805 (EQH22_10300) comGD/cglD 1910005..1910409 (-) 405 WP_000588030.1 competence type IV pilus minor pilin ComGD Machinery gene
  EQH22_RS09810 (EQH22_10305) comGC/cglC 1910402..1910728 (-) 327 WP_000738625.1 competence type IV pilus major pilin ComGC Machinery gene
  EQH22_RS09815 (EQH22_10310) comGB/cglB 1910730..1911746 (-) 1017 WP_074017570.1 competence type IV pilus assembly protein ComGB Machinery gene
  EQH22_RS09820 (EQH22_10315) comGA/cglA/cilD 1911694..1912635 (-) 942 WP_000249555.1 competence type IV pilus ATPase ComGA Machinery gene
  EQH22_RS09825 (EQH22_10320) - 1912710..1913075 (-) 366 WP_000286415.1 DUF1033 family protein -
  EQH22_RS09830 (EQH22_10325) - 1913226..1914284 (-) 1059 WP_000649471.1 zinc-dependent alcohol dehydrogenase family protein -
  EQH22_RS09835 (EQH22_10330) nagA 1914447..1915598 (-) 1152 WP_001134457.1 N-acetylglucosamine-6-phosphate deacetylase -
  EQH22_RS09840 (EQH22_10335) - 1915751..1917568 (-) 1818 WP_001220850.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 313 a.a.        Molecular weight: 35561.49 Da        Isoelectric Point: 6.0083

>NTDB_id=338188 EQH22_RS09820 WP_000249555.1 1911694..1912635(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901927]
MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYA
YDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHELSKSLFKGQQ
VMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVY
ERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Nucleotide


Download         Length: 942 bp        

>NTDB_id=338188 EQH22_RS09820 WP_000249555.1 1911694..1912635(-) (comGA/cglA/cilD) [Streptococcus pneumoniae strain TVO_1901927]
ATGGTTCAAGAAATTGCACAAGAAATCATTCGTTCGGCTCGGAAAAAAGGGGCGCAAGACATTTATTTTGTCCCCAAGTT
AGATGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGCTGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCG
TTATCAGTCACTTTAAGTTTGTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAGAGTTTGGTTATCCGTTTGTT
GCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGATATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCT
ATCTTTTTGCTGGTCCGGTTGGGAGTGGTAAGACGACCTTGATGCATGAATTGTCCAAGTCACTCTTTAAAGGACAGCAA
GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGACATGCTTCAGTTGCAGTTGAACGAAGCAATCGGCCTAAC
CTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCAGATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGG
CGCGTGCAGTGGTCAGAGCTAGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTCTGCTACCAGAGATTAATCGG
GGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAAGAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGC
TTCTTAAAGATGGACATATCACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-266)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae D39

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae R6

98.722

100

0.987
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

98.722

100

0.987
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

97.125

100

0.971
  comYA Streptococcus gordonii str. Challis substr. CH1

78.065

99.042

0.773
  comYA Streptococcus mutans UA159

66.238

99.361

0.658
  comYA Streptococcus mutans UA140

66.238

99.361

0.658
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

62.903

99.042

0.623
  comGA Lactococcus lactis subsp. cremoris KW2

55.128

99.681

0.55
  comGA Latilactobacillus sakei subsp. sakei 23K

41.912

86.901

0.364

Multiple sequence alignment