Detailed information NTG0033353

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SP70585_RS11735
• Genome accession: NC_012468
• Coordinates: 2179504..2180256 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae 70585
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2174504..2185256

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP70585_RS14355	-	2176937..2178540 (-)	1604	Protein_2195	YhgE/Pip family protein	-
SP70585_RS11720 (SP70585_2361)	-	2178719..2179261 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SP70585_RS11735 (SP70585_2364)	comE	2179504..2180256 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SP70585_RS11740 (SP70585_2365)	comD/comD1	2180253..2181578 (-)	1326	WP_015898772.1	competence system sensor histidine kinase ComD	Regulator
SP70585_RS11745 (SP70585_2366)	comC/comC1	2181599..2181724 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SP70585_RS11755 (SP70585_2368)	rlmH	2182007..2182486 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SP70585_RS11760 (SP70585_2369)	htrA	2182669..2183850 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
SP70585_RS11765 (SP70585_2370)	spo0J	2183908..2184666 (+)	759	WP_000410384.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=33353 SP70585_RS11735 WP_000866065.1 2179504..2180256(-) (comE) [Streptococcus pneumoniae 70585]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=33353 SP70585_RS11735 WP_000866065.1 2179504..2180256(-) (comE) [Streptococcus pneumoniae 70585]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTTTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408