Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   SP70585_RS11740 Genome accession   NC_012468
Coordinates   2180253..2181578 (-) Length   441 a.a.
NCBI ID   WP_015898772.1    Uniprot ID   C1CBL3
Organism   Streptococcus pneumoniae 70585     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2175253..2186578
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SP70585_RS14355 - 2176937..2178540 (-) 1604 Protein_2195 YhgE/Pip family protein -
  SP70585_RS11720 (SP70585_2361) - 2178719..2179261 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  SP70585_RS11735 (SP70585_2364) comE 2179504..2180256 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  SP70585_RS11740 (SP70585_2365) comD/comD1 2180253..2181578 (-) 1326 WP_015898772.1 competence system sensor histidine kinase ComD Regulator
  SP70585_RS11745 (SP70585_2366) comC/comC1 2181599..2181724 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  SP70585_RS11755 (SP70585_2368) rlmH 2182007..2182486 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SP70585_RS11760 (SP70585_2369) htrA 2182669..2183850 (+) 1182 WP_000681598.1 S1C family serine protease Regulator
  SP70585_RS11765 (SP70585_2370) spo0J 2183908..2184666 (+) 759 WP_000410384.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51173.64 Da        Isoelectric Point: 6.9339

>NTDB_id=33354 SP70585_RS11740 WP_015898772.1 2180253..2181578(-) (comD/comD1) [Streptococcus pneumoniae 70585]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=33354 SP70585_RS11740 WP_015898772.1 2180253..2181578(-) (comD/comD1) [Streptococcus pneumoniae 70585]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGCTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTGACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTCGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGGATGCTTGTCAGTATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTCAAAGCAAATCATAAACTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C1CBL3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.639

100

0.986
  comD/comD1 Streptococcus pneumoniae D39

98.639

100

0.986
  comD/comD1 Streptococcus pneumoniae R6

98.639

100

0.986
  comD/comD2 Streptococcus pneumoniae TIGR4

96.372

100

0.964
  comD Streptococcus mitis SK321

92.971

100

0.93
  comD Streptococcus mitis NCTC 12261

86.848

100

0.868
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.202

85.261

0.42
  comD/comD2 Streptococcus gordonii strain NCTC7865

48.936

85.261

0.417

Multiple sequence alignment