Detailed information NTG0033356

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SP70585_RS11760
• Genome accession: NC_012468
• Coordinates: 2182669..2183850 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681598.1
• Uniprot ID: A0A0B7M448
• Organism: Streptococcus pneumoniae 70585
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2177669..2188850

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SP70585_RS11720 (SP70585_2361)	-	2178719..2179261 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SP70585_RS11735 (SP70585_2364)	comE	2179504..2180256 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SP70585_RS11740 (SP70585_2365)	comD/comD1	2180253..2181578 (-)	1326	WP_015898772.1	competence system sensor histidine kinase ComD	Regulator
SP70585_RS11745 (SP70585_2366)	comC/comC1	2181599..2181724 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SP70585_RS11755 (SP70585_2368)	rlmH	2182007..2182486 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SP70585_RS11760 (SP70585_2369)	htrA	2182669..2183850 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
SP70585_RS11765 (SP70585_2370)	spo0J	2183908..2184666 (+)	759	WP_000410384.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41827.69 Da
• Isoelectric Point: 6.8902

>NTDB_id=33356 SP70585_RS11760 WP_000681598.1 2182669..2183850(+) (htrA) [Streptococcus pneumoniae 70585]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=33356 SP70585_RS11760 WP_000681598.1 2182669..2183850(+) (htrA) [Streptococcus pneumoniae 70585]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7M448

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.746	100	0.997
htrA	Streptococcus pneumoniae D39	99.746	100	0.997
htrA	Streptococcus pneumoniae R6	99.746	100	0.997
htrA	Streptococcus pneumoniae TIGR4	99.746	100	0.997
htrA	Streptococcus mitis NCTC 12261	97.455	100	0.975
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.822	100	0.55