Detailed information NTG0030057

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPH_RS11900
• Genome accession: NC_010380
• Coordinates: 2240439..2241191 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866070.1
• Uniprot ID: B1IAE5
• Organism: Streptococcus pneumoniae Hungary19A-6
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2235439..2246191

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPH_RS11870 (SPH_2426)	-	2235788..2238340 (+)	2553	WP_000834682.1	YfhO family protein	-
SPH_RS14275	-	2238370..2239547 (-)	1178	Protein_2234	YhgE/Pip family protein	-
SPH_RS11885 (SPH_2429)	-	2239654..2240196 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SPH_RS11900 (SPH_2432)	comE	2240439..2241191 (-)	753	WP_000866070.1	competence system response regulator transcription factor ComE	Regulator
SPH_RS11905 (SPH_2433)	comD/comD1	2241188..2242513 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
SPH_RS11910 (SPH_2434)	comC/comC1	2242534..2242659 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPH_RS11920 (SPH_2437)	rlmH	2242941..2243419 (-)	479	Protein_2239	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPH_RS11925 (SPH_2438)	htrA	2243602..2244783 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
SPH_RS11930 (SPH_2439)	spo0J	2244841..2245599 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29948.27 Da
• Isoelectric Point: 6.5073

>NTDB_id=30057 SPH_RS11900 WP_000866070.1 2240439..2241191(-) (comE) [Streptococcus pneumoniae Hungary19A-6]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSSHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=30057 SPH_RS11900 WP_000866070.1 2240439..2241191(-) (comE) [Streptococcus pneumoniae Hungary19A-6]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATATCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTTCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: B1IAE5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	99.6	100	0.996
comE	Streptococcus pneumoniae D39	99.6	100	0.996
comE	Streptococcus pneumoniae R6	99.6	100	0.996
comE	Streptococcus pneumoniae TIGR4	99.6	100	0.996
comE	Streptococcus mitis SK321	98.8	100	0.988
comE	Streptococcus mitis NCTC 12261	98	100	0.98
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.4	100	0.624
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.4	100	0.624
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408