Detailed information NTG0030060

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SPH_RS11925
• Genome accession: NC_010380
• Coordinates: 2243602..2244783 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681601.1
• Uniprot ID: A0A0B7LRW6
• Organism: Streptococcus pneumoniae Hungary19A-6
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2238602..2249783

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPH_RS11885 (SPH_2429)	-	2239654..2240196 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SPH_RS11900 (SPH_2432)	comE	2240439..2241191 (-)	753	WP_000866070.1	competence system response regulator transcription factor ComE	Regulator
SPH_RS11905 (SPH_2433)	comD/comD1	2241188..2242513 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
SPH_RS11910 (SPH_2434)	comC/comC1	2242534..2242659 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPH_RS11920 (SPH_2437)	rlmH	2242941..2243419 (-)	479	Protein_2239	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPH_RS11925 (SPH_2438)	htrA	2243602..2244783 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
SPH_RS11930 (SPH_2439)	spo0J	2244841..2245599 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41855.70 Da
• Isoelectric Point: 6.8902

>NTDB_id=30060 SPH_RS11925 WP_000681601.1 2243602..2244783(+) (htrA) [Streptococcus pneumoniae Hungary19A-6]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLRSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=30060 SPH_RS11925 WP_000681601.1 2243602..2244783(+) (htrA) [Streptococcus pneumoniae Hungary19A-6]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTAGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAGATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0B7LRW6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	99.491	100	0.995
htrA	Streptococcus pneumoniae D39	99.491	100	0.995
htrA	Streptococcus pneumoniae R6	99.491	100	0.995
htrA	Streptococcus pneumoniae TIGR4	99.491	100	0.995
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.919	100	0.674
htrA	Streptococcus mutans UA159	54.822	100	0.55