Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   SPH_RS11905 Genome accession   NC_010380
Coordinates   2241188..2242513 (-) Length   441 a.a.
NCBI ID   WP_000362880.1    Uniprot ID   Q79CK8
Organism   Streptococcus pneumoniae Hungary19A-6     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2236188..2247513
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPH_RS14275 - 2238370..2239547 (-) 1178 Protein_2234 YhgE/Pip family protein -
  SPH_RS11885 (SPH_2429) - 2239654..2240196 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  SPH_RS11900 (SPH_2432) comE 2240439..2241191 (-) 753 WP_000866070.1 competence system response regulator transcription factor ComE Regulator
  SPH_RS11905 (SPH_2433) comD/comD1 2241188..2242513 (-) 1326 WP_000362880.1 competence system sensor histidine kinase ComD Regulator
  SPH_RS11910 (SPH_2434) comC/comC1 2242534..2242659 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  SPH_RS11920 (SPH_2437) rlmH 2242941..2243419 (-) 479 Protein_2239 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SPH_RS11925 (SPH_2438) htrA 2243602..2244783 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  SPH_RS11930 (SPH_2439) spo0J 2244841..2245599 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51353.78 Da        Isoelectric Point: 6.6400

>NTDB_id=30058 SPH_RS11905 WP_000362880.1 2241188..2242513(-) (comD/comD1) [Streptococcus pneumoniae Hungary19A-6]
MDLFGFGTVIVHFLIISHSYHFICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=30058 SPH_RS11905 WP_000362880.1 2241188..2242513(-) (comD/comD1) [Streptococcus pneumoniae Hungary19A-6]
ATGGATTTATTTGGATTTGGGACGGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCATTTTATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGAAAGATTTTTATTTCCTTTGGGATTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q79CK8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

100

100

1
  comD/comD1 Streptococcus pneumoniae D39

100

100

1
  comD/comD1 Streptococcus pneumoniae R6

100

100

1
  comD/comD2 Streptococcus pneumoniae TIGR4

96.825

100

0.968
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.168

100

0.862
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422

Multiple sequence alignment