Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   CWI64_RS09660 Genome accession   NZ_CP025076
Coordinates   1794378..1795115 (+) Length   245 a.a.
NCBI ID   WP_001219120.1    Uniprot ID   Q9S1I6
Organism   Streptococcus pneumoniae strain BHN97x     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1789378..1800115
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI64_RS11715 - 1790309..1790548 (-) 240 WP_001812223.1 hypothetical protein -
  CWI64_RS09625 (CWI64_09625) - 1790710..1790997 (-) 288 WP_000777760.1 hypothetical protein -
  CWI64_RS09630 (CWI64_09630) - 1791007..1791417 (-) 411 WP_001278301.1 HIT family protein -
  CWI64_RS09635 (CWI64_09635) pptA 1791485..1792216 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  CWI64_RS09640 (CWI64_09640) - 1792213..1793262 (+) 1050 WP_000653766.1 ABC transporter permease -
  CWI64_RS09650 (CWI64_09650) - 1793430..1793759 (-) 330 WP_000132572.1 hypothetical protein -
  CWI64_RS09655 (CWI64_09655) - 1794035..1794373 (+) 339 WP_000876675.1 LytTR family DNA-binding domain-containing protein -
  CWI64_RS09660 (CWI64_09660) comE/blpR 1794378..1795115 (+) 738 WP_001219120.1 LytTR family DNA-binding domain-containing protein Regulator
  CWI64_RS09665 (CWI64_09665) - 1795129..1796469 (+) 1341 WP_001017644.1 sensor histidine kinase -
  CWI64_RS09670 (CWI64_09670) blpC 1796511..1796666 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  CWI64_RS09675 (CWI64_09675) - 1796723..1798084 (-) 1362 WP_001069082.1 bacteriocin secretion accessory protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28754.98 Da        Isoelectric Point: 6.5884

>NTDB_id=258121 CWI64_RS09660 WP_001219120.1 1794378..1795115(+) (comE/blpR) [Streptococcus pneumoniae strain BHN97x]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=258121 CWI64_RS09660 WP_001219120.1 1794378..1795115(+) (comE/blpR) [Streptococcus pneumoniae strain BHN97x]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCTGAAGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1I6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.46

96.735

0.42
  comE/comE2 Streptococcus equinus JB1

38.017

98.776

0.376
  comE Streptococcus infantis strain Atu-4

35.887

100

0.363

Multiple sequence alignment