Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/comE2   Type   Regulator
Locus tag   CO687_RS03080 Genome accession   NZ_CP023511
Coordinates   642989..643756 (+) Length   255 a.a.
NCBI ID   WP_008808031.1    Uniprot ID   P75031
Organism   Streptococcus gordonii strain FDAARGOS_371     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 641454..664393 642989..643756 within 0


Gene organization within MGE regions


Location: 641454..664393
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO687_RS03070 (CO687_03070) comC/comC1 641454..641618 (+) 165 WP_080998577.1 bacteriocin Regulator
  CO687_RS03075 (CO687_03075) comD/comD2 641631..642992 (+) 1362 WP_301335837.1 competence system sensor histidine kinase ComD Regulator
  CO687_RS03080 (CO687_03080) comE/comE2 642989..643756 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  CO687_RS03095 (CO687_03095) ychF 644078..645193 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -
  CO687_RS03100 (CO687_03100) pth 645267..645836 (+) 570 WP_096754921.1 aminoacyl-tRNA hydrolase -
  CO687_RS03105 (CO687_03105) mfd 645829..649332 (+) 3504 WP_096754922.1 transcription-repair coupling factor -
  CO687_RS03110 (CO687_03110) - 649398..649664 (+) 267 WP_012131074.1 RNA-binding S4 domain-containing protein -
  CO687_RS03115 (CO687_03115) - 649657..650025 (+) 369 WP_060970645.1 septum formation initiator family protein -
  CO687_RS03120 (CO687_03120) - 650028..650147 (+) 120 WP_037622626.1 SP_0009 family protein -
  CO687_RS03125 (CO687_03125) - 650147..651427 (+) 1281 WP_045772579.1 serine hydrolase -
  CO687_RS03130 (CO687_03130) tilS 651424..652701 (+) 1278 WP_008808024.1 tRNA lysidine(34) synthetase TilS -
  CO687_RS03135 (CO687_03135) hpt 652706..653248 (+) 543 WP_060970644.1 hypoxanthine phosphoribosyltransferase -
  CO687_RS03140 (CO687_03140) ftsH 653267..655249 (+) 1983 WP_046164766.1 ATP-dependent zinc metalloprotease FtsH -
  CO687_RS03155 (CO687_03155) comR/comR2 655778..656260 (+) 483 WP_048778891.1 sigma-70 family RNA polymerase sigma factor Regulator
  CO687_RS03265 (CO687_03265) mreC 663076..663891 (+) 816 WP_061596025.1 rod shape-determining protein MreC -
  CO687_RS03270 (CO687_03270) mreD 663893..664393 (+) 501 WP_061602340.1 rod shape-determining protein MreD -

Sequence

Protein


Download         Length: 255 a.a.        Molecular weight: 30225.48 Da        Isoelectric Point: 7.0651

>NTDB_id=247944 CO687_RS03080 WP_008808031.1 642989..643756(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS_371]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide


Download         Length: 768 bp        

>NTDB_id=247944 CO687_RS03080 WP_008808031.1 642989..643756(+) (comE/comE2) [Streptococcus gordonii strain FDAARGOS_371]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGTCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGTATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTTTATAT
ATTGAGACAACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTCTATGGGACAATAGCAGA
AATTCAGGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACACAAGTCATACCTATCTAATATTAGCAATATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATATTTA
AAAGAAATACTGAAAGCAAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P75031

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/comE2 Streptococcus gordonii strain NCTC7865

100

100

1
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

100

100

1
  comE Streptococcus infantis strain Atu-4

64

98.039

0.627
  comE Streptococcus mitis NCTC 12261

64

98.039

0.627
  comE Streptococcus mitis SK321

63.2

98.039

0.62
  comE Streptococcus pneumoniae Rx1

62.8

98.039

0.616
  comE Streptococcus pneumoniae D39

62.8

98.039

0.616
  comE Streptococcus pneumoniae R6

62.8

98.039

0.616
  comE Streptococcus pneumoniae TIGR4

62.8

98.039

0.616
  comE/blpR Streptococcus mutans UA159

37.551

96.078

0.361

Multiple sequence alignment