Detailed information NTG0217321

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: CWI64_RS06920
• Genome accession: NZ_CP025076
• Coordinates: 1287979..1288731 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866075.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain BHN97x
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1282979..1293731

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CWI64_RS06895 (CWI64_06895)	-	1283906..1285159 (+)	1254	WP_000649625.1	IS110 family transposase	-
CWI64_RS06900 (CWI64_06900)	-	1285419..1285961 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
CWI64_RS06915 (CWI64_06915)	-	1286322..1287719 (+)	1398	WP_001812112.1	ISNCY-like element IS1202 family transposase	-
CWI64_RS06920 (CWI64_06920)	comE	1287979..1288731 (-)	753	WP_000866075.1	competence system response regulator transcription factor ComE	Regulator
CWI64_RS06925 (CWI64_06925)	comD/comD1	1288728..1290053 (-)	1326	WP_025169508.1	competence system sensor histidine kinase ComD	Regulator
CWI64_RS06930 (CWI64_06930)	comC	1290066..1290197 (-)	132	WP_061649796.1	competence-stimulating peptide ComC	Regulator
CWI64_RS06940 (CWI64_06940)	rlmH	1290479..1290958 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
CWI64_RS06945 (CWI64_06945)	htrA	1291141..1292322 (+)	1182	WP_000681598.1	S1C family serine protease	Regulator
CWI64_RS06950 (CWI64_06950)	spo0J	1292380..1293138 (+)	759	WP_000410381.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29930.26 Da
• Isoelectric Point: 6.5073

>NTDB_id=217321 CWI64_RS06920 WP_000866075.1 1287979..1288731(-) (comE) [Streptococcus pneumoniae strain BHN97x]
MKVLILEDVIEHQVRLERILDEISKESNTPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQISALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHAQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=217321 CWI64_RS06920 WP_000866075.1 1287979..1288731(-) (comE) [Streptococcus pneumoniae strain BHN97x]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATACTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTTGCTCAACTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTGACCTATAAATACCAGATATCAGCCCTAGATTT
TGTTGATAAGGATATCAACGATGAGATGTTTAAGAAGCGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGAGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATGCTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	98.8	100	0.988
comE	Streptococcus pneumoniae D39	98.8	100	0.988
comE	Streptococcus pneumoniae R6	98.8	100	0.988
comE	Streptococcus pneumoniae TIGR4	98.8	100	0.988
comE	Streptococcus mitis SK321	98	100	0.98
comE	Streptococcus mitis NCTC 12261	97.2	100	0.972
comE	Streptococcus infantis strain Atu-4	90	100	0.9
comE/comE2	Streptococcus gordonii strain NCTC7865	62.4	100	0.624
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.4	100	0.624
comE/blpR	Streptococcus mutans UA159	40.891	98.8	0.404