Detailed information NTG0194004

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: BFM96_RS02990
• Genome accession: NZ_CP016953
• Coordinates: 601584..602327 (+)
• Length: 247 a.a.
• NCBI ID: WP_068990101.1
• Uniprot ID: A0A917A2Q4
• Organism: Streptococcus himalayensis strain HTS2
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 596584..607327

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BFM96_RS02965	spo0J	597144..597911 (-)	768	WP_068990086.1	ParB/RepB/Spo0J family partition protein	Regulator
BFM96_RS02970	htrA	597974..599149 (-)	1176	WP_068990089.1	S1C family serine protease	Regulator
BFM96_RS02975	rlmH	599354..599833 (+)	480	WP_068990092.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
BFM96_RS10785	-	600115..600249 (+)	135	WP_083201733.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
BFM96_RS02985	comD/comD2	600265..601587 (+)	1323	WP_068990095.1	GHKL domain-containing protein	Regulator
BFM96_RS02990	comE/comE2	601584..602327 (+)	744	WP_068990101.1	competence system response regulator transcription factor ComE	Regulator
BFM96_RS11430	-	602555..602680 (+)	126	WP_262981929.1	hypothetical protein	-
BFM96_RS03005	-	602833..605421 (-)	2589	WP_068990103.1	YfhO family protein	-
BFM96_RS03010	-	605626..607248 (-)	1623	WP_068990105.1	ATP-binding cassette domain-containing protein	-

Sequence

Protein

• Length: 247 a.a.
• Molecular weight: 28825.87 Da
• Isoelectric Point: 5.7088

>NTDB_id=194004 BFM96_RS02990 WP_068990101.1 601584..602327(+) (comE/comE2) [Streptococcus himalayensis strain HTS2]
MKVLVLEDELTHQIRMESTLATISEEMGFAIKVTTTGKISEFKEYVENEEVNQLYFLDIDIKGEETKGLEIARFIRQHNP
YAIIVFVTTKSEFATLTFKYKVSALDFIDKNLGDDAFKEHIQSAIEYTKSTLLENQDMVDYFEYSYRGGEVRIPYQDILY
IETTGASHKLRIVGKNFFKEFYGTISDIQEKDEKSNRFFSCHKSYLANIGNIQGYDKKSKEIIFYENHRCPITRMKVGKL
KTLLEEK

Nucleotide

• Length: 744 bp

>NTDB_id=194004 BFM96_RS02990 WP_068990101.1 601584..602327(+) (comE/comE2) [Streptococcus himalayensis strain HTS2]
ATGAAAGTTTTAGTATTGGAAGATGAATTGACTCATCAAATTCGAATGGAGAGCACTTTAGCAACTATTTCAGAGGAGAT
GGGATTTGCAATCAAAGTGACAACTACCGGGAAAATTAGTGAATTTAAGGAATATGTCGAAAATGAAGAAGTGAATCAGC
TATATTTCTTAGATATTGATATAAAAGGGGAAGAGACAAAAGGATTAGAAATTGCTCGTTTTATTCGTCAGCACAATCCT
TATGCCATTATTGTGTTTGTGACCACGAAATCAGAATTTGCAACCTTGACCTTTAAATATAAGGTGTCAGCACTTGATTT
TATTGATAAAAATTTGGGGGATGATGCCTTTAAAGAACACATTCAAAGTGCTATCGAATATACTAAATCAACCTTGCTTG
AAAATCAAGATATGGTCGATTATTTCGAATATAGCTACCGTGGTGGTGAGGTCAGAATTCCTTATCAGGATATTCTTTAT
ATTGAGACAACAGGTGCTTCTCATAAACTACGGATTGTAGGGAAGAATTTCTTTAAGGAATTTTATGGAACCATTTCTGA
TATTCAAGAAAAAGATGAGAAAAGCAATCGTTTTTTCTCTTGTCATAAGTCTTATTTAGCAAATATTGGGAATATTCAAG
GCTATGATAAGAAAAGCAAGGAAATTATTTTTTATGAAAATCATCGCTGTCCAATTACTCGAATGAAAGTTGGCAAATTA
AAAACTTTGTTGGAAGAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	66.397	100	0.664
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	66.397	100	0.664
comE	Streptococcus infantis strain Atu-4	65.587	100	0.656
comE	Streptococcus mitis NCTC 12261	65.587	100	0.656
comE	Streptococcus mitis SK321	64.777	100	0.648
comE	Streptococcus pneumoniae Rx1	64.372	100	0.644
comE	Streptococcus pneumoniae D39	64.372	100	0.644
comE	Streptococcus pneumoniae R6	64.372	100	0.644
comE	Streptococcus pneumoniae TIGR4	64.372	100	0.644
comE/blpR	Streptococcus mutans UA159	40.323	100	0.405