Detailed information NTG0157730

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SanJ4211_RS09650
• Genome accession: NZ_CP012805
• Coordinates: 1919307..1920056 (-)
• Length: 249 a.a.
• NCBI ID: WP_021002244.1
• Uniprot ID: -
• Organism: Streptococcus anginosus strain J4211
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1914307..1925056

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SanJ4211_RS09630 (SanJ4211_1919)	-	1914694..1916316 (+)	1623	WP_003026810.1	ATP-binding cassette domain-containing protein	-
SanJ4211_RS09635 (SanJ4211_1920)	-	1916383..1918959 (+)	2577	WP_057489850.1	YfhO family protein	-
SanJ4211_RS09650 (SanJ4211_1921c)	comE	1919307..1920056 (-)	750	WP_021002244.1	competence system response regulator transcription factor ComE	Regulator
SanJ4211_RS09655 (SanJ4211_1922c)	comD/comD2	1920056..1921378 (-)	1323	WP_021002245.1	sensor histidine kinase	Regulator
SanJ4211_RS09930 (SanJ4211_1923c)	-	1921393..1921542 (-)	150	WP_021002246.1	bacteriocin	-
SanJ4211_RS09665 (SanJ4211_1924c)	rlmH	1921824..1922303 (-)	480	WP_041784074.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SanJ4211_RS09670 (SanJ4211_1925)	htrA	1922497..1923687 (+)	1191	WP_021002247.1	S1C family serine protease	Regulator
SanJ4211_RS09675 (SanJ4211_1926)	spo0J	1923742..1924509 (+)	768	WP_021002248.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29201.91 Da
• Isoelectric Point: 9.2138

>NTDB_id=157730 SanJ4211_RS09650 WP_021002244.1 1919307..1920056(-) (comE) [Streptococcus anginosus strain J4211]
MKVLVLEDEISHQVRMETTLAEIAKEMGITIKVKVTGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLSDVAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDKKTRRFFSPHKSYLVNIGNIKGYDKKMREIIFYEDHRCPITRMKIGKL
KAILEELKG

Nucleotide

• Length: 750 bp

>NTDB_id=157730 SanJ4211_RS09650 WP_021002244.1 1919307..1920056(-) (comE) [Streptococcus anginosus strain J4211]
ATGAAAGTATTGGTATTAGAAGATGAAATTTCACATCAAGTAAGAATGGAAACAACTTTGGCAGAGATTGCGAAAGAAAT
GGGAATTACGATAAAAGTTAAAGTAACTGGCAAAGTAAGAGAATTTAAAGAATATATTGAAAATGATGAGGTGAATCAAT
TATATTTTTTAGATATTGATATCAAAGGAGAGGAAACAAAAGGTTTAGAAATAGCAAAATTTATACGTCATCACAATCCG
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACGATGACCTTCAAATATAAGGTATCTGCACTGGATTT
TGTTGATAAAAATTTGAGTGATGTTGCTTTTAAAAAACATATAAAAGACAGCATTGAGTATACAAAAGCGACATTGATTG
AAAATAAAGATATGGTGGATTATTTTGAATACAGCTTTCGTGGCGGAGAGGTTAGAATGCCTTTTAATGACATTTTATAT
ATTGAAACGACAGGCTCTTCTCATAAATTAAGAATTGTCGGTAAAAACTTTTTTAAAGAATTCTATGGCACTATTGCAGA
TATTCAAGAAAAAGATAAAAAAACAAGACGTTTCTTTTCACCTCATAAATCCTACCTAGTCAATATTGGAAACATCAAAG
GTTATGACAAAAAAATGCGAGAAATAATTTTTTATGAAGATCATCGTTGTCCGATTACTCGAATGAAAATTGGAAAATTA
AAAGCTATTTTAGAGGAATTAAAAGGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	70.612	98.394	0.695
comE	Streptococcus infantis strain Atu-4	69.796	98.394	0.687
comE	Streptococcus mitis SK321	69.796	98.394	0.687
comE/comE2	Streptococcus gordonii strain NCTC7865	70.082	97.992	0.687
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	70.082	97.992	0.687
comE	Streptococcus pneumoniae Rx1	69.388	98.394	0.683
comE	Streptococcus pneumoniae D39	69.388	98.394	0.683
comE	Streptococcus pneumoniae R6	69.388	98.394	0.683
comE	Streptococcus pneumoniae TIGR4	69.388	98.394	0.683
comE/blpR	Streptococcus mutans UA159	40.486	99.197	0.402
comE/comE2	Streptococcus equinus JB1	35.135	100	0.365