Detailed information NTG0135438

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: RN86_RS03055
• Genome accession: NZ_CP012648
• Coordinates: 651543..652310 (+)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain KCOM 1506 (= ChDC B679)
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 646543..657310

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RN86_RS03025 (RN86_03020)	spo0J	647026..647790 (-)	765	WP_045504981.1	ParB/RepB/Spo0J family partition protein	Regulator
RN86_RS03030 (RN86_03025)	htrA	647856..649049 (-)	1194	WP_045504979.1	S1C family serine protease	Regulator
RN86_RS03035 (RN86_03030)	rlmH	649243..649722 (+)	480	WP_008808034.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
RN86_RS11220	comC/comC1	650008..650172 (+)	165	WP_080998577.1	bacteriocin	Regulator
RN86_RS03050 (RN86_03045)	comD/comD2	650185..651546 (+)	1362	WP_052721528.1	competence system sensor histidine kinase ComD	Regulator
RN86_RS03055 (RN86_03050)	comE/comE2	651543..652310 (+)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
RN86_RS03070 (RN86_03065)	ychF	652632..653747 (+)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
RN86_RS03075 (RN86_03070)	pth	653821..654390 (+)	570	WP_046164770.1	aminoacyl-tRNA hydrolase	-

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=135438 RN86_RS03055 WP_008808031.1 651543..652310(+) (comE/comE2) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=135438 RN86_RS03055 WP_008808031.1 651543..652310(+) (comE/comE2) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGTCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGTATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTTTATAT
ATTGAGACAACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTCTATGGGACAATAGCAGA
AATTCAGGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACACAAGTCATACCTATCTAATATTAGCAATATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATATTTA
AAAGAAATACTGAAAGCAAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361