Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   RN86_RS03030 Genome accession   NZ_CP012648
Coordinates   647856..649049 (-) Length   397 a.a.
NCBI ID   WP_045504979.1    Uniprot ID   -
Organism   Streptococcus gordonii strain KCOM 1506 (= ChDC B679)     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 642856..654049
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN86_RS03005 (RN86_03000) - 643438..643956 (+) 519 WP_045504988.1 YehR family protein -
  RN86_RS03010 (RN86_03005) - 643975..644178 (-) 204 WP_008808039.1 DUF951 family protein -
  RN86_RS03015 (RN86_03010) dnaN 644178..645314 (-) 1137 WP_008808038.1 DNA polymerase III subunit beta -
  RN86_RS03020 (RN86_03015) dnaA 645470..646822 (-) 1353 WP_053794273.1 chromosomal replication initiator protein DnaA -
  RN86_RS03025 (RN86_03020) spo0J 647026..647790 (-) 765 WP_045504981.1 ParB/RepB/Spo0J family partition protein Regulator
  RN86_RS03030 (RN86_03025) htrA 647856..649049 (-) 1194 WP_045504979.1 S1C family serine protease Regulator
  RN86_RS03035 (RN86_03030) rlmH 649243..649722 (+) 480 WP_008808034.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RN86_RS11220 comC/comC1 650008..650172 (+) 165 WP_080998577.1 bacteriocin Regulator
  RN86_RS03050 (RN86_03045) comD/comD2 650185..651546 (+) 1362 WP_052721528.1 competence system sensor histidine kinase ComD Regulator
  RN86_RS03055 (RN86_03050) comE/comE2 651543..652310 (+) 768 WP_008808031.1 competence system response regulator transcription factor ComE Regulator
  RN86_RS03070 (RN86_03065) ychF 652632..653747 (+) 1116 WP_008808030.1 redox-regulated ATPase YchF -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42237.96 Da        Isoelectric Point: 5.4938

>NTDB_id=135436 RN86_RS03030 WP_045504979.1 647856..649049(-) (htrA) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
MKNSSNFFKKTLQVFIVLLVGFIGGVAGTWGFSYFSTPHSAVNNNQKTATTITTSYKNSNSTTKAVDKVKDAVVSVITYS
ESNSDTIFDNNNSGNENDQVASEGSGVIYRKDKDYAYLVTNTHVINGAKKVDIRLADGNKVPGEIVGTDTYSDISVVRIP
ADKVKNVAEFGDSSKLTVGETAIAIGSPLGSDYANTVTQGIVSSLSRNVSSRSEDGQTIATQAIQTDAAINPGNSGGPLV
NIQGQVIGITSSKIANTNNGSTSVEGMGFAIPSNDVVNIIEQLEKNGKVIRPALGIQMVNLSSLSSSSSDRLKLPENVKN
GVVVRSTQTGMPADGKLQKYDVITKIDDTEISSASDIQSALYKHSINEEIKVTYYRDGKEQTTTIKLTKSTDDLSSE

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=135436 RN86_RS03030 WP_045504979.1 647856..649049(-) (htrA) [Streptococcus gordonii strain KCOM 1506 (= ChDC B679)]
ATGAAAAACTCTTCAAATTTCTTCAAAAAAACATTGCAAGTTTTCATTGTTTTGTTAGTTGGTTTTATAGGTGGTGTTGC
TGGAACATGGGGATTTTCTTATTTTTCAACACCTCATTCAGCCGTAAATAATAATCAGAAAACAGCAACTACAATAACAA
CATCCTATAAAAATAGTAATTCTACAACAAAGGCTGTTGATAAAGTAAAAGATGCTGTTGTCTCTGTCATTACATATTCT
GAATCTAATTCGGATACTATTTTTGACAACAATAATTCAGGAAATGAAAATGATCAGGTAGCTAGCGAAGGATCTGGTGT
TATCTATAGAAAAGATAAAGACTATGCTTACTTAGTTACCAATACACACGTTATCAATGGAGCAAAAAAAGTTGATATCC
GTCTTGCTGATGGGAATAAGGTTCCTGGTGAAATAGTCGGGACTGATACATATTCTGATATTTCTGTAGTCAGAATTCCT
GCCGATAAGGTTAAAAATGTAGCAGAATTTGGGGATTCTAGTAAATTAACTGTTGGGGAAACTGCCATTGCAATCGGAAG
TCCTCTTGGATCTGATTATGCTAATACAGTAACTCAGGGAATTGTTTCTAGTCTAAGCCGTAATGTTTCTTCACGATCAG
AAGATGGTCAAACAATTGCTACCCAAGCTATTCAAACTGATGCAGCAATTAATCCAGGTAACTCTGGTGGTCCTCTTGTA
AACATTCAAGGTCAAGTTATTGGTATTACCTCTAGTAAAATTGCTAACACCAATAATGGTAGTACTTCTGTTGAGGGAAT
GGGATTTGCAATCCCATCCAATGATGTTGTAAATATCATTGAACAATTAGAAAAGAATGGTAAAGTCATTCGACCAGCAT
TAGGAATTCAAATGGTCAACTTAAGTAGTTTGTCTTCTTCAAGCTCTGATCGATTAAAACTTCCAGAAAATGTTAAGAAT
GGTGTCGTTGTTCGTTCCACACAAACTGGAATGCCTGCTGATGGTAAGTTACAAAAATATGATGTGATTACAAAAATTGA
CGATACAGAAATATCATCTGCTAGCGATATCCAATCAGCTCTTTATAAACATTCAATTAATGAAGAAATTAAAGTTACTT
ATTATCGTGATGGAAAAGAGCAAACAACAACTATTAAACTAACTAAATCAACTGATGATTTAAGTTCTGAATAA

Domains

Predicted by InterProScan.

Peptidase family M50 (Peptidase_M50)

(236-391)

PDZ domain (PDZ_2)

(292-387)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

98.489

100

0.985
  htrA Streptococcus pneumoniae Rx1

66.414

99.748

0.662
  htrA Streptococcus pneumoniae D39

66.414

99.748

0.662
  htrA Streptococcus pneumoniae R6

66.414

99.748

0.662
  htrA Streptococcus pneumoniae TIGR4

66.414

99.748

0.662
  htrA Streptococcus mitis NCTC 12261

66.08

100

0.662
  htrA Streptococcus mutans UA159

56.14

100

0.564

Multiple sequence alignment