Detailed information NTG1170481

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACLV7W_RS10800
• Genome accession: NZ_OZ217346
• Coordinates: 2215079..2215831 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866073.1
• Uniprot ID: A0A081S8D7
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2210079..2220831

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS10780 (SMID22_22150)	-	2211525..2214167 (-)	2643	WP_411865925.1	YhgE/Pip family protein	-
ACLV7W_RS10785 (SMID22_22160)	-	2214294..2214836 (+)	543	WP_001158275.1	TetR/AcrR family transcriptional regulator	-
ACLV7W_RS10800 (SMID22_22190)	comE	2215079..2215831 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
ACLV7W_RS10805 (SMID22_22200)	comD	2215828..2217147 (-)	1320	WP_411865926.1	competence system sensor histidine kinase ComD	Regulator
ACLV7W_RS10810 (SMID22_22210)	comC/comC1	2217167..2217292 (-)	126	WP_411865927.1	competence-stimulating peptide ComC	Regulator
ACLV7W_RS10820 (SMID22_22230)	rlmH	2217575..2218054 (-)	480	WP_000695928.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7W_RS10825 (SMID22_22240)	htrA	2218238..2219419 (+)	1182	WP_000681589.1	S1C family serine protease	Regulator
ACLV7W_RS10830 (SMID22_22250)	spo0J	2219477..2220235 (+)	759	WP_000410371.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29947.32 Da
• Isoelectric Point: 6.9819

>NTDB_id=1170481 ACLV7W_RS10800 WP_000866073.1 2215079..2215831(-) (comE) [Streptococcus mitis isolate S. mitis D22]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1170481 ACLV7W_RS10800 WP_000866073.1 2215079..2215831(-) (comE) [Streptococcus mitis isolate S. mitis D22]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTTCGTGAATTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTTCTAGATATTGATATTCATGGAATTGAGAAAAAAGGGTTTGAAGTTGCTCAGTTTATTCGTCATCACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGTTGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTTGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACGACAGGTGTCTCTCATAAATTACGCATTATTGGTAAGAATTTTGCCAAAGAGTTTTACGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGGAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGATCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTCTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (151-244)

3D structure

• AlphaFold DB: A0A081S8D7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus pneumoniae Rx1	98.4	100	0.984
comE	Streptococcus pneumoniae D39	98.4	100	0.984
comE	Streptococcus pneumoniae R6	98.4	100	0.984
comE	Streptococcus pneumoniae TIGR4	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	92.8	100	0.928
comE/comE2	Streptococcus gordonii strain NCTC7865	64	100	0.64
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	64	100	0.64
comE/blpR	Streptococcus mutans UA159	41.7	98.8	0.412