Detailed information NTG1170484

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACLV7W_RS10825
• Genome accession: NZ_OZ217346
• Coordinates: 2218238..2219419 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681589.1
• Uniprot ID: A0A0F2DH46
• Organism: Streptococcus mitis isolate S. mitis D22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2213238..2224419

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7W_RS10785 (SMID22_22160)	-	2214294..2214836 (+)	543	WP_001158275.1	TetR/AcrR family transcriptional regulator	-
ACLV7W_RS10800 (SMID22_22190)	comE	2215079..2215831 (-)	753	WP_000866073.1	competence system response regulator transcription factor ComE	Regulator
ACLV7W_RS10805 (SMID22_22200)	comD	2215828..2217147 (-)	1320	WP_411865926.1	competence system sensor histidine kinase ComD	Regulator
ACLV7W_RS10810 (SMID22_22210)	comC/comC1	2217167..2217292 (-)	126	WP_411865927.1	competence-stimulating peptide ComC	Regulator
ACLV7W_RS10820 (SMID22_22230)	rlmH	2217575..2218054 (-)	480	WP_000695928.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7W_RS10825 (SMID22_22240)	htrA	2218238..2219419 (+)	1182	WP_000681589.1	S1C family serine protease	Regulator
ACLV7W_RS10830 (SMID22_22250)	spo0J	2219477..2220235 (+)	759	WP_000410371.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41651.47 Da
• Isoelectric Point: 6.1475

>NTDB_id=1170484 ACLV7W_RS10825 WP_000681589.1 2218238..2219419(+) (htrA) [Streptococcus mitis isolate S. mitis D22]
MKHLKTFYKKGFQLLVVIVISFISGALGSFSINQLTQKSTVSTSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNINTSDLRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1170484 ACLV7W_RS10825 WP_000681589.1 2218238..2219419(+) (htrA) [Streptococcus mitis isolate S. mitis D22]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTATTAGTGGAGCCTT
GGGTAGCTTTTCAATAAACCAACTAACTCAAAAAAGTACTGTAAGTACCTCTAACAACAATAGTACTATTACACAGACTG
CCTATAAGAATGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCAGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGTAATGATGATACTGACACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGGGTTAT
TTATAAAAAGAATGACAAAGAAGCTTACATCGTCACCAATAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGTT
TGTCAGATGGAACTAAAGTACCCGGAGAAATTGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCCATTGCTATTGGTAGCCC
ATTGGGTTCTGAATATGCAAATACTGTCACTCAGGGTATTGTATCTAGTCTTAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTAATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCAACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTTGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACTCGTCCAGCTTTGGGAATTC
AAATGGTCAATCTCTCAAATATTAATACAAGTGATCTTAGAAGACTGAATATTCCAAGTAACGTAACATCTGGTGTCGTT
GTTCGTTCTGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
CATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATAACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCTATTAAACTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

3D structure

• AlphaFold DB: A0A0F2DH46

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.982	100	0.99
htrA	Streptococcus pneumoniae Rx1	96.692	100	0.967
htrA	Streptococcus pneumoniae D39	96.692	100	0.967
htrA	Streptococcus pneumoniae R6	96.692	100	0.967
htrA	Streptococcus pneumoniae TIGR4	96.692	100	0.967
htrA	Streptococcus gordonii str. Challis substr. CH1	66.499	100	0.672
htrA	Streptococcus mutans UA159	54.569	100	0.547