Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD   Type   Regulator
Locus tag   ACLV7W_RS10805 Genome accession   NZ_OZ217346
Coordinates   2215828..2217147 (-) Length   439 a.a.
NCBI ID   WP_411865926.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis D22     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2210828..2222147
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7W_RS10780 (SMID22_22150) - 2211525..2214167 (-) 2643 WP_411865925.1 YhgE/Pip family protein -
  ACLV7W_RS10785 (SMID22_22160) - 2214294..2214836 (+) 543 WP_001158275.1 TetR/AcrR family transcriptional regulator -
  ACLV7W_RS10800 (SMID22_22190) comE 2215079..2215831 (-) 753 WP_000866073.1 competence system response regulator transcription factor ComE Regulator
  ACLV7W_RS10805 (SMID22_22200) comD 2215828..2217147 (-) 1320 WP_411865926.1 competence system sensor histidine kinase ComD Regulator
  ACLV7W_RS10810 (SMID22_22210) comC/comC1 2217167..2217292 (-) 126 WP_411865927.1 competence-stimulating peptide ComC Regulator
  ACLV7W_RS10820 (SMID22_22230) rlmH 2217575..2218054 (-) 480 WP_000695928.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACLV7W_RS10825 (SMID22_22240) htrA 2218238..2219419 (+) 1182 WP_000681589.1 S1C family serine protease Regulator
  ACLV7W_RS10830 (SMID22_22250) spo0J 2219477..2220235 (+) 759 WP_000410371.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 439 a.a.        Molecular weight: 51014.82 Da        Isoelectric Point: 8.4686

>NTDB_id=1170482 ACLV7W_RS10805 WP_411865926.1 2215828..2217147(-) (comD) [Streptococcus mitis isolate S. mitis D22]
MNLLGFGIVIVYFLIVSKSYERICKITKKERIVFLCYTGISVFILEEVASMVYRDGFSLVKFLFPLVIYFYLRKLKMYEI
YKGIFISILLSLLYNGTHTFISVTLSSITGDYLVSQHEEIFYFIVLLLTYFSIKKIITYFHLELNYFDKDYLYPFLKKVF
FALLLLHVASFVSDMVSTIKHLNSFGSILSSIVFISLFLTFFAMNSYKEQKEKEIALKQKKFEQKHLQNYTDEIVGLYNE
IRGFRHDYAGMLVSMQMAIDSGNLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEFTL
EVKDIITRLPIDLLDLVRIMSVLLNNAVEGSADSYKKHMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGRNR
GVGLNNVKELLDKYNNIILETEMEGSIFRQIIRFKREFE

Nucleotide


Download         Length: 1320 bp        

>NTDB_id=1170482 ACLV7W_RS10805 WP_411865926.1 2215828..2217147(-) (comD) [Streptococcus mitis isolate S. mitis D22]
ATGAATTTATTGGGATTTGGGATAGTTATTGTTTATTTTTTAATCGTTAGCAAAAGTTATGAACGGATTTGTAAAATAAC
TAAAAAAGAGCGTATAGTTTTTTTATGTTACACAGGTATATCAGTTTTTATACTTGAAGAAGTTGCTAGTATGGTATATA
GAGATGGCTTTAGTCTAGTTAAATTTTTATTTCCATTAGTTATATATTTTTATTTAAGAAAATTGAAGATGTATGAAATA
TACAAAGGAATTTTTATTAGTATACTATTATCTTTGTTATATAATGGTACCCATACTTTTATATCTGTAACGTTATCTTC
AATTACAGGAGATTATTTAGTATCCCAGCATGAAGAAATTTTCTATTTTATAGTTCTATTACTAACTTATTTTTCAATCA
AAAAAATTATTACTTATTTCCACTTGGAATTGAACTATTTTGATAAGGATTACCTTTATCCTTTCTTGAAAAAAGTATTT
TTTGCTTTACTACTGCTACATGTTGCATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTAAATAGTTTTGGAAG
TATTTTATCATCTATTGTCTTTATCTCTTTATTTTTGACCTTCTTTGCAATGAATTCTTATAAAGAACAAAAGGAGAAAG
AGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAAAACTACACAGATGAAATTGTCGGTCTATATAATGAA
ATCCGTGGCTTTCGACATGATTATGCTGGTATGCTTGTTAGTATGCAGATGGCAATTGACAGTGGTAATTTACAGGAAAT
TGACAGAGTTTACAATGAAGTTTTGGTCAAAGCCAATCACAAACTGCGTTCAGATAAGTACACTTACTTTGATTTAAACA
ACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTTACACTG
GAAGTAAAAGATATAATTACTAGACTACCAATAGACCTTCTGGATTTGGTTCGTATTATGAGTGTTTTATTGAACAATGC
TGTCGAAGGATCGGCTGATAGTTATAAAAAACATATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTATTGTGA
TTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCTACTAAGGGAAGAAATCGT
GGGGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAATAACATTATTTTAGAAACAGAGATGGAAGGCAGTAT
ATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(333-432)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD Streptococcus mitis SK321

82.766

100

0.831
  comD/comD2 Streptococcus pneumoniae TIGR4

81.633

100

0.82
  comD Streptococcus mitis NCTC 12261

80.813

100

0.815
  comD/comD1 Streptococcus pneumoniae D39

81.179

100

0.815
  comD/comD1 Streptococcus pneumoniae R6

81.179

100

0.815
  comD/comD1 Streptococcus pneumoniae Rx1

81.179

100

0.815
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

48.711

88.383

0.431
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.649

0.424

Multiple sequence alignment