Detailed information NTG1170321

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACLV7A_RS09905
• Genome accession: NZ_OZ217344
• Coordinates: 2079353..2080105 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2074353..2085105

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS09885 (SMIE22_19790)	-	2075798..2078440 (-)	2643	WP_411864198.1	YhgE/Pip family protein	-
ACLV7A_RS09890 (SMIE22_19800)	-	2078568..2079110 (+)	543	WP_001158275.1	TetR/AcrR family transcriptional regulator	-
ACLV7A_RS09905 (SMIE22_19830)	comE	2079353..2080105 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV7A_RS09910 (SMIE22_19840)	comD/comD2	2080102..2081427 (-)	1326	WP_050242851.1	competence system sensor histidine kinase ComD	Regulator
ACLV7A_RS09915 (SMIE22_19850)	comC/comC1	2081448..2081573 (-)	126	WP_000799687.1	competence-stimulating peptide ComC	Regulator
ACLV7A_RS09925 (SMIE22_19870)	rlmH	2081854..2082333 (-)	480	WP_411864199.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7A_RS09930 (SMIE22_19880)	htrA	2082516..2083697 (+)	1182	WP_050242853.1	S1C family serine protease	Regulator
ACLV7A_RS09935 (SMIE22_19890)	spo0J	2083755..2084513 (+)	759	WP_050252627.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=1170321 ACLV7A_RS09905 WP_000866065.1 2079353..2080105(-) (comE) [Streptococcus mitis isolate S. mitis E22]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=1170321 ACLV7A_RS09905 WP_000866065.1 2079353..2080105(-) (comE) [Streptococcus mitis isolate S. mitis E22]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAGTC
GAATATTCCAATATCATACAAGACAACAGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAACGACGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACCAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCTTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTATAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGACATTCTGTAT
ATTGAAACGACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTCTATGGAACAATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGAGATTTTATTCTCCTCATAAGTCATTTTTGGTAAATATAGGCAATATTAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGATCATCGCTGTCCTATTTCAAGGTTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408