Detailed information NTG1170324

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACLV7A_RS09930
• Genome accession: NZ_OZ217344
• Coordinates: 2082516..2083697 (+)
• Length: 393 a.a.
• NCBI ID: WP_050242853.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2077516..2088697

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS09890 (SMIE22_19800)	-	2078568..2079110 (+)	543	WP_001158275.1	TetR/AcrR family transcriptional regulator	-
ACLV7A_RS09905 (SMIE22_19830)	comE	2079353..2080105 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV7A_RS09910 (SMIE22_19840)	comD/comD2	2080102..2081427 (-)	1326	WP_050242851.1	competence system sensor histidine kinase ComD	Regulator
ACLV7A_RS09915 (SMIE22_19850)	comC/comC1	2081448..2081573 (-)	126	WP_000799687.1	competence-stimulating peptide ComC	Regulator
ACLV7A_RS09925 (SMIE22_19870)	rlmH	2081854..2082333 (-)	480	WP_411864199.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7A_RS09930 (SMIE22_19880)	htrA	2082516..2083697 (+)	1182	WP_050242853.1	S1C family serine protease	Regulator
ACLV7A_RS09935 (SMIE22_19890)	spo0J	2083755..2084513 (+)	759	WP_050252627.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41614.40 Da
• Isoelectric Point: 6.1475

>NTDB_id=1170324 ACLV7A_RS09930 WP_050242853.1 2082516..2083697(+) (htrA) [Streptococcus mitis isolate S. mitis E22]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSIAQLTQKSSVSNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNISTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKDIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1170324 ACLV7A_RS09930 WP_050242853.1 2082516..2083697(+) (htrA) [Streptococcus mitis isolate S. mitis E22]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTAGTGTAAGCAACTCTAATAACAATAGCACCATTACACAGACTG
CCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCCGTTATTACTTATTCAGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGAACTAAAGTACCTGGAGAAATCGTCGGAGCGGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATTGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTCAATCGAAATGTATCCTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGTGGCCCACTGATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAGGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATATAAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGCGTAGTT
GTTCGTTCTGTACAAAGTAATATGCCTGCCAATGGTCACCTCGAAAAATACGATGTGATTACAAAAGTGGATGATAAAGA
TATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATTACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCCATCAAGCTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (289-384)

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.473	100	0.985
htrA	Streptococcus pneumoniae D39	97.964	100	0.98
htrA	Streptococcus pneumoniae R6	97.964	100	0.98
htrA	Streptococcus pneumoniae Rx1	97.964	100	0.98
htrA	Streptococcus pneumoniae TIGR4	97.964	100	0.98
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.822	100	0.55