Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   ACLV7A_RS09915 Genome accession   NZ_OZ217344
Coordinates   2081448..2081573 (-) Length   41 a.a.
NCBI ID   WP_000799687.1    Uniprot ID   A0A1S9ZPR2
Organism   Streptococcus mitis isolate S. mitis E22     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2076448..2086573
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS09890 (SMIE22_19800) - 2078568..2079110 (+) 543 WP_001158275.1 TetR/AcrR family transcriptional regulator -
  ACLV7A_RS09905 (SMIE22_19830) comE 2079353..2080105 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACLV7A_RS09910 (SMIE22_19840) comD/comD2 2080102..2081427 (-) 1326 WP_050242851.1 competence system sensor histidine kinase ComD Regulator
  ACLV7A_RS09915 (SMIE22_19850) comC/comC1 2081448..2081573 (-) 126 WP_000799687.1 competence-stimulating peptide ComC Regulator
  ACLV7A_RS09925 (SMIE22_19870) rlmH 2081854..2082333 (-) 480 WP_411864199.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACLV7A_RS09930 (SMIE22_19880) htrA 2082516..2083697 (+) 1182 WP_050242853.1 S1C family serine protease Regulator
  ACLV7A_RS09935 (SMIE22_19890) spo0J 2083755..2084513 (+) 759 WP_050252627.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4916.01 Da        Isoelectric Point: 11.0775

>NTDB_id=1170323 ACLV7A_RS09915 WP_000799687.1 2081448..2081573(-) (comC/comC1) [Streptococcus mitis isolate S. mitis E22]
MKNTVKLEQFVALKEKDLQKIKGGEMRLPKILRDFIFPRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=1170323 ACLV7A_RS09915 WP_000799687.1 2081448..2081573(-) (comC/comC1) [Streptococcus mitis isolate S. mitis E22]
ATGAAAAATACAGTTAAATTGGAACAGTTTGTAGCCTTGAAGGAAAAAGACTTGCAAAAGATTAAAGGTGGGGAAATGAG
ACTTCCAAAAATCCTCCGTGATTTTATTTTCCCAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1S9ZPR2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

87.805

100

0.878
  comC/comC1 Streptococcus pneumoniae G54

87.805

100

0.878
  comC/comC1 Streptococcus pneumoniae D39

87.805

100

0.878
  comC/comC1 Streptococcus pneumoniae Rx1

87.805

100

0.878
  comC Streptococcus mitis SK321

87.805

100

0.878
  comC/comC2 Streptococcus pneumoniae A66

82.927

100

0.829
  comC/comC2 Streptococcus pneumoniae TIGR4

82.927

100

0.829
  comC Streptococcus mitis NCTC 12261

74.074

65.854

0.488

Multiple sequence alignment