Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   ACLV7A_RS09910 Genome accession   NZ_OZ217344
Coordinates   2080102..2081427 (-) Length   441 a.a.
NCBI ID   WP_050242851.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis E22     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 2075102..2086427
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS09885 (SMIE22_19790) - 2075798..2078440 (-) 2643 WP_411864198.1 YhgE/Pip family protein -
  ACLV7A_RS09890 (SMIE22_19800) - 2078568..2079110 (+) 543 WP_001158275.1 TetR/AcrR family transcriptional regulator -
  ACLV7A_RS09905 (SMIE22_19830) comE 2079353..2080105 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  ACLV7A_RS09910 (SMIE22_19840) comD/comD2 2080102..2081427 (-) 1326 WP_050242851.1 competence system sensor histidine kinase ComD Regulator
  ACLV7A_RS09915 (SMIE22_19850) comC/comC1 2081448..2081573 (-) 126 WP_000799687.1 competence-stimulating peptide ComC Regulator
  ACLV7A_RS09925 (SMIE22_19870) rlmH 2081854..2082333 (-) 480 WP_411864199.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACLV7A_RS09930 (SMIE22_19880) htrA 2082516..2083697 (+) 1182 WP_050242853.1 S1C family serine protease Regulator
  ACLV7A_RS09935 (SMIE22_19890) spo0J 2083755..2084513 (+) 759 WP_050252627.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51254.68 Da        Isoelectric Point: 6.7809

>NTDB_id=1170322 ACLV7A_RS09910 WP_050242851.1 2080102..2081427(-) (comD/comD2) [Streptococcus mitis isolate S. mitis E22]
MNLFGFGTVIGHFLIISHSYRLICKGQIKSKELYFFGLYTLLVEAVLELSFYLLYLDEIVIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVSQYHAPFFFVVTVLTYVVVLKIIHYFHLELTYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTVKHLNSFGSILSSIVFISLLLTFFAMNSHKEQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGDLQEIDRVYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGIGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=1170322 ACLV7A_RS09910 WP_050242851.1 2080102..2081427(-) (comD/comD2) [Streptococcus mitis isolate S. mitis E22]
ATGAATTTATTTGGATTTGGGACAGTTATTGGTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCA
AATAAAATCAAAGGAACTATATTTTTTTGGTCTCTATACATTACTAGTAGAAGCAGTACTTGAACTTTCCTTTTATCTTC
TATATTTAGATGAAATAGTGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCTTCTATAACAGGAGACAATTTTGTTTCACAATATCATGCCCCATTCTTTTTCGTTGTAACGGTGTTGACCTATGTTG
TTGTCTTAAAAATCATTCATTATTTCCATTTGGAACTAACCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCCTTACTACTGCTCCATATTGTATCTTTCGTTTCAGATATGGTAAGTACGGTTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTTTTTATCTCGTTACTTTTGACCTTCTTTGCAATGAATTCGCATAAAGAACAAATGG
AAAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTATACAGATGAAATTGTCGGACTGTAT
AATGAAATCCGTGGTTTTCGACATGACTATGCTGGAATGCTTGTCAGTATGCAGATGGCAATTGACAGTGGTGATTTACA
GGAAATTGACAGAGTTTACAATGAAGTTTTGGTTAAAGCTAATCACAAACTGCGTTCAGATAAGTACACTTACTTTGATT
TGAATAACATAGAAGATTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACTAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
CAATGCTGTTGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCTTTAGGATTCTCTACTAAGGGAAGA
AATCGCGGAATTGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATTATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

94.331

100

0.943
  comD/comD1 Streptococcus pneumoniae Rx1

92.744

100

0.927
  comD/comD1 Streptococcus pneumoniae D39

92.744

100

0.927
  comD/comD1 Streptococcus pneumoniae R6

92.744

100

0.927
  comD Streptococcus mitis SK321

90.703

100

0.907
  comD Streptococcus mitis NCTC 12261

86.848

100

0.868
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.465

84.807

0.419

Multiple sequence alignment