Detailed information NTG1169993

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: ACLV7H_RS09910
• Genome accession: NZ_OZ217340
• Coordinates: 1946247..1946999 (-)
• Length: 250 a.a.
• NCBI ID: WP_045592607.1
• Uniprot ID: -
• Organism: Streptococcus oralis isolate S. oralis A22
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1941247..1951999

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7H_RS09890 (SORA22_19930)	-	1942687..1945341 (-)	2655	WP_411867056.1	YhgE/Pip family protein	-
ACLV7H_RS09895 (SORA22_19940)	-	1945470..1946012 (+)	543	WP_411867057.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
ACLV7H_RS09910 (SORA22_19970)	comE	1946247..1946999 (-)	753	WP_045592607.1	competence system response regulator transcription factor ComE	Regulator
ACLV7H_RS09915 (SORA22_19980)	comD	1946996..1948315 (-)	1320	Protein_1906	competence system sensor histidine kinase ComD	-
ACLV7H_RS09920 (SORA22_19990)	comC/comC2	1948336..1948461 (-)	126	WP_000799678.1	competence-stimulating peptide ComC	Regulator
ACLV7H_RS09930 (SORA22_20010)	rlmH	1948743..1949222 (-)	480	WP_411867058.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7H_RS09935 (SORA22_20020)	htrA	1949409..1950602 (+)	1194	WP_411867059.1	S1C family serine protease	Regulator
ACLV7H_RS09940 (SORA22_20030)	spo0J	1950660..1951418 (+)	759	WP_411867060.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29898.26 Da
• Isoelectric Point: 6.9755

>NTDB_id=1169993 ACLV7H_RS09910 WP_045592607.1 1946247..1946999(-) (comE) [Streptococcus oralis isolate S. oralis A22]
MKVLILEDVIEHQVRLERILNEISEESNIPISYKTTGKVREFKEYIENDEVNQLYFLDIDIHGIEKKGFEVAQFIRHHNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDELFKKRIEQSIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYCSHKSFLVNVGNVREIDRKNLEVVFYEDHRCPITRLKVRKL
KDILEKKTKK

Nucleotide

• Length: 753 bp

>NTDB_id=1169993 ACLV7H_RS09910 WP_045592607.1 1946247..1946999(-) (comE) [Streptococcus oralis isolate S. oralis A22]
ATGAAAGTATTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTAAATGAAATCTCTGAGGAATC
GAATATTCCTATTTCATATAAGACAACAGGAAAAGTTCGTGAGTTTAAGGAATATATCGAAAATGATGAAGTAAACCAGC
TTTATTTCCTAGATATCGATATTCATGGAATCGAGAAAAAAGGCTTTGAAGTGGCTCAGTTTATCCGTCATCACAATCCT
TACGCTATTATTGTCTTTATTACCAGTCGATCTGAATTTGCTACCTTAACGTACAAATACCAGGTATCAGCCCTAGATTT
TGTCGATAAAGATATCAATGATGAATTGTTCAAAAAACGCATCGAGCAGAGTATTTTTTACACTAAGAGCATGCTGCTTG
AAAACGAAGATGTTGTAGACTATTTTGATTACAACTATAAAGGAAATGATTTGAAAATTCCTTACCATGACATTTTGTAT
ATCGAAACCACAGGAGTTTCTCATAAACTTCGGATTATTGGTAAGAATTTTGCTAAAGAATTCTATGGAACTATGACAGA
TATTCAGGAAAAGGACAAACATACCCAGCGATTTTATTGCTCCCATAAATCTTTCCTTGTCAATGTGGGAAATGTGAGAG
AAATTGATCGAAAGAATTTAGAAGTTGTCTTTTATGAAGATCATCGTTGTCCAATTACTCGTTTAAAAGTCCGCAAACTA
AAAGATATTCTAGAGAAAAAAACTAAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	95.2	100	0.952
comE	Streptococcus mitis SK321	94.4	100	0.944
comE	Streptococcus pneumoniae Rx1	93.6	100	0.936
comE	Streptococcus pneumoniae D39	93.6	100	0.936
comE	Streptococcus pneumoniae R6	93.6	100	0.936
comE	Streptococcus pneumoniae TIGR4	93.6	100	0.936
comE	Streptococcus infantis strain Atu-4	93.2	100	0.932
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	40.486	98.8	0.4