Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ACLV7H_RS09935 Genome accession   NZ_OZ217340
Coordinates   1949409..1950602 (+) Length   397 a.a.
NCBI ID   WP_411867059.1    Uniprot ID   -
Organism   Streptococcus oralis isolate S. oralis A22     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1944409..1955602
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7H_RS09895 (SORA22_19940) - 1945470..1946012 (+) 543 WP_411867057.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
  ACLV7H_RS09910 (SORA22_19970) comE 1946247..1946999 (-) 753 WP_045592607.1 competence system response regulator transcription factor ComE Regulator
  ACLV7H_RS09915 (SORA22_19980) comD 1946996..1948315 (-) 1320 Protein_1906 competence system sensor histidine kinase ComD -
  ACLV7H_RS09920 (SORA22_19990) comC/comC2 1948336..1948461 (-) 126 WP_000799678.1 competence-stimulating peptide ComC Regulator
  ACLV7H_RS09930 (SORA22_20010) rlmH 1948743..1949222 (-) 480 WP_411867058.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ACLV7H_RS09935 (SORA22_20020) htrA 1949409..1950602 (+) 1194 WP_411867059.1 S1C family serine protease Regulator
  ACLV7H_RS09940 (SORA22_20030) spo0J 1950660..1951418 (+) 759 WP_411867060.1 ParB/RepB/Spo0J family partition protein Regulator
  ACLV7H_RS09945 - 1951635..1952063 (+) 429 Protein_1911 hypothetical protein -

Sequence

Protein


Download         Length: 397 a.a.        Molecular weight: 42013.81 Da        Isoelectric Point: 6.6581

>NTDB_id=1169995 ACLV7H_RS09935 WP_411867059.1 1949409..1950602(+) (htrA) [Streptococcus oralis isolate S. oralis A22]
MKHLQKFYKKGVKVLVIILIGFLSGALGSFVTLQLYQKQGNQSTNNNSGTVTQTSYKNENSTTQAVNKVKDAVVSIITYS
SNSRQSSVFNADETNSDSDNQQIASEGSGVIYKKDDKDAYLVTNTHVINGASKVDVRLADGTKVPGEIVGSDTFSDIAVV
KISSEKVTTVAEFGDSSQLSVGETAIAIGSPLGSEYANTVTQGIISSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGG
PLVNIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDAQNIIKQLESNGKVTRPALGIQMVNLSNVGASDLRKLNIPSSLT
SGVVVRSVQNNMPANGHLQKYDVITKVDDKEITSSTDLQHALYNHAIGDTIKVTYYRNGKEETTSIKLDKNSADLES

Nucleotide


Download         Length: 1194 bp        

>NTDB_id=1169995 ACLV7H_RS09935 WP_411867059.1 1949409..1950602(+) (htrA) [Streptococcus oralis isolate S. oralis A22]
ATGAAACACTTACAAAAATTTTACAAAAAAGGAGTTAAAGTTCTTGTAATCATTCTAATCGGATTTTTAAGTGGTGCCTT
AGGAAGTTTTGTAACATTACAACTTTATCAAAAACAAGGAAATCAATCTACGAATAATAACTCTGGCACTGTCACTCAAA
CATCCTATAAAAATGAAAACTCAACTACTCAAGCAGTAAATAAAGTTAAAGATGCTGTTGTCTCAATCATTACTTATTCT
TCAAATAGTAGACAAAGTAGTGTATTTAATGCTGATGAAACTAATTCTGATTCAGACAATCAACAAATCGCAAGTGAGGG
ATCAGGTGTTATCTATAAAAAAGATGATAAAGATGCCTATCTTGTAACTAATACTCACGTTATCAATGGAGCTTCAAAAG
TTGATGTCCGCTTAGCAGATGGTACCAAGGTTCCTGGTGAAATTGTCGGATCTGATACTTTCTCTGATATTGCTGTCGTT
AAAATTTCTTCAGAAAAAGTTACAACAGTAGCAGAATTTGGGGATTCAAGCCAACTTAGTGTTGGAGAAACAGCGATTGC
TATTGGTAGTCCTCTAGGTTCAGAATATGCTAATACAGTTACACAGGGAATCATCTCAAGTCTTAATCGAAATGTTTCTC
TAAAATCTGAAGATGGTCAAGCTATTTCAACAAAAGCCATTCAAACAGATACGGCTATTAACCCTGGTAACTCTGGTGGT
CCACTTGTAAACATTCAAGGACAAGTAATTGGTATTACATCAAGTAAAATTGCAAGTAATGGTGGAACATCTGTAGAAGG
TCTTGGTTTTGCAATTCCTTCAAACGATGCACAAAATATCATTAAACAGCTTGAAAGTAATGGTAAAGTGACTCGTCCAG
CTCTTGGAATTCAAATGGTCAATCTGTCAAATGTTGGAGCTAGTGATCTTAGAAAACTTAACATTCCAAGTAGCCTCACT
TCAGGTGTAGTTGTTCGATCTGTTCAAAACAATATGCCAGCAAATGGACATCTTCAAAAATACGATGTCATTACCAAAGT
TGACGACAAAGAGATTACCTCATCAACAGACCTACAACACGCTCTTTACAATCATGCTATTGGAGATACTATAAAAGTAA
CCTACTACCGTAACGGTAAGGAGGAAACAACCTCTATAAAACTAGATAAGAATTCTGCTGATTTAGAGTCTTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(293-388)

Trypsin-like peptidase domain (Trypsin_2)

(107-252)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

83.627

100

0.836
  htrA Streptococcus pneumoniae Rx1

82.872

100

0.829
  htrA Streptococcus pneumoniae D39

82.872

100

0.829
  htrA Streptococcus pneumoniae R6

82.872

100

0.829
  htrA Streptococcus pneumoniae TIGR4

82.872

100

0.829
  htrA Streptococcus gordonii str. Challis substr. CH1

66.334

100

0.67
  htrA Streptococcus mutans UA159

54.707

98.992

0.542

Multiple sequence alignment