Detailed information NTG0114372

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SSAL8618_RS08585
• Genome accession: NZ_CP009913
• Coordinates: 1868780..1869520 (+)
• Length: 246 a.a.
• NCBI ID: WP_014634987.1
• Uniprot ID: -
• Organism: Streptococcus salivarius strain NCTC 8618
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1863780..1874520

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SSAL8618_RS08560 (SSAL8618_08560)	-	1863862..1866129 (+)	2268	WP_038676696.1	Xaa-Pro dipeptidyl-peptidase	-
SSAL8618_RS08565 (SSAL8618_08565)	-	1866209..1866589 (-)	381	WP_038676698.1	hypothetical protein	-
SSAL8618_RS08570 (SSAL8618_08570)	-	1866714..1867079 (-)	366	WP_013991116.1	hypothetical protein	-
SSAL8618_RS08575 (SSAL8618_08575)	-	1867297..1867593 (-)	297	WP_038676700.1	bacteriocin immunity protein	-
SSAL8618_RS10450 (SSAL8618_08580)	-	1868392..1868526 (-)	135	Protein_1667	Blp family class II bacteriocin	-
SSAL8618_RS08585 (SSAL8618_08585)	comE/blpR	1868780..1869520 (+)	741	WP_014634987.1	response regulator transcription factor	Regulator
SSAL8618_RS10890	comD/comD3	1870102..1870851 (+)	750	WP_014634988.1	sensor histidine kinase	Regulator
SSAL8618_RS10935 (SSAL8618_08595)	-	1870938..1871339 (-)	402	WP_038676702.1	hypothetical protein	-
SSAL8618_RS10650 (SSAL8618_08600)	-	1871668..1871835 (-)	168	WP_002884432.1	hypothetical protein	-
SSAL8618_RS08610 (SSAL8618_08610)	-	1872312..1872542 (-)	231	WP_021143664.1	bacteriocin class II family protein	-
SSAL8618_RS08615 (SSAL8618_08615)	-	1872702..1874447 (-)	1746	WP_038676705.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28677.27 Da
• Isoelectric Point: 8.4293

>NTDB_id=114372 SSAL8618_RS08585 WP_014634987.1 1868780..1869520(+) (comE/blpR) [Streptococcus salivarius strain NCTC 8618]
MDIYILEDNLIQQGRLEMVLSQELKKYNKDLSIVHTFDKPQQFIEAIDSTTSNQLFFLDIEIKGEKLKGLDIAKIIREKN
PYATIIFVTTHSEFMPLVFDYQVSALDYIDKSLSEIEFRKKITRALAITMKPLGIENDEIFDFQTQHTAIRIPLNQVIYI
ETSPQKHYVILHGTNNQMTFRANLKDLEKASPSLVSCHRSYLINPNNIIRINKLKREVEMTDGSICPFSRTKAKMLMDTF
KRRNLQ

Nucleotide

• Length: 741 bp

>NTDB_id=114372 SSAL8618_RS08585 WP_014634987.1 1868780..1869520(+) (comE/blpR) [Streptococcus salivarius strain NCTC 8618]
TTGGATATATATATCTTAGAGGACAATCTCATTCAACAAGGACGACTGGAGATGGTATTGTCTCAAGAGTTAAAAAAATA
CAATAAAGACTTATCTATTGTACACACCTTTGATAAGCCTCAGCAATTTATAGAAGCGATTGATTCAACAACTTCTAACC
AGCTCTTTTTTCTTGATATCGAAATTAAGGGAGAAAAATTAAAAGGGCTCGATATTGCTAAAATCATTAGGGAAAAAAAT
CCCTACGCTACTATTATCTTTGTCACTACCCACTCAGAGTTTATGCCACTAGTTTTTGATTACCAAGTATCTGCCCTAGA
CTATATTGATAAAAGTCTCTCTGAAATAGAATTTAGGAAAAAGATAACCAGAGCTTTAGCTATAACTATGAAACCACTTG
GAATAGAGAATGACGAGATTTTTGATTTTCAAACACAACATACAGCTATTCGCATACCTTTAAACCAAGTTATCTATATT
GAAACTTCTCCGCAAAAGCATTATGTGATACTCCATGGTACAAACAATCAAATGACCTTTCGTGCAAATCTAAAGGACCT
TGAAAAAGCTAGTCCTTCACTCGTATCTTGCCATCGTTCGTATCTCATTAACCCTAACAACATTATAAGAATCAACAAAT
TAAAACGTGAAGTCGAAATGACTGATGGTAGTATCTGTCCTTTTTCACGTACCAAAGCTAAAATGCTGATGGATACTTTT
AAAAGAAGGAACCTTCAATGA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (150-239)

• Response regulator receiver domain (Response_reg) (18-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	43.59	95.122	0.415
comE/comE2	Streptococcus equinus JB1	39.241	96.341	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	37.2	100	0.378
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.2	100	0.378
comE/comE1	Streptococcus equinus JB1	38.655	96.748	0.374
comE	Streptococcus pneumoniae TIGR4	35.6	100	0.362
comE	Streptococcus mitis SK321	35.6	100	0.362
comE	Streptococcus mitis NCTC 12261	35.6	100	0.362
comE	Streptococcus infantis strain Atu-4	35.6	100	0.362
comE	Streptococcus pneumoniae Rx1	35.6	100	0.362
comE	Streptococcus pneumoniae D39	35.6	100	0.362
comE	Streptococcus pneumoniae R6	35.6	100	0.362