Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE   Type   Regulator
Locus tag   DQL01_RS11720 Genome accession   NZ_LS483451
Coordinates   2195156..2195908 (-) Length   250 a.a.
NCBI ID   WP_000866065.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 4041STDY6836166     
Function   activate transcription of early competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2190156..2200908
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DQL01_RS12805 - 2192589..2194192 (-) 1604 Protein_2196 YhgE/Pip family protein -
  DQL01_RS11705 - 2194371..2194913 (+) 543 WP_001158268.1 TetR/AcrR family transcriptional regulator -
  DQL01_RS11720 comE 2195156..2195908 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  DQL01_RS11725 comD/comD2 2195905..2197230 (-) 1326 WP_016397292.1 competence system sensor histidine kinase ComD Regulator
  DQL01_RS11730 comC/comC2 2197251..2197376 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  DQL01_RS11740 rlmH 2197658..2198137 (-) 480 WP_061757162.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  DQL01_RS11745 htrA 2198320..2199501 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  DQL01_RS11750 spo0J 2199559..2200317 (+) 759 WP_050087436.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 250 a.a.        Molecular weight: 29958.31 Da        Isoelectric Point: 6.5073

>NTDB_id=1142105 DQL01_RS11720 WP_000866065.1 2195156..2195908(-) (comE) [Streptococcus pneumoniae strain 4041STDY6836166]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide


Download         Length: 753 bp        

>NTDB_id=1142105 DQL01_RS11720 WP_000866065.1 2195156..2195908(-) (comE) [Streptococcus pneumoniae strain 4041STDY6836166]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-244)

Response regulator receiver domain (Response_reg)

(3-121)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE Streptococcus pneumoniae Rx1

100

100

1
  comE Streptococcus pneumoniae D39

100

100

1
  comE Streptococcus pneumoniae R6

100

100

1
  comE Streptococcus pneumoniae TIGR4

100

100

1
  comE Streptococcus mitis SK321

99.2

100

0.992
  comE Streptococcus mitis NCTC 12261

98.4

100

0.984
  comE Streptococcus infantis strain Atu-4

91.2

100

0.912
  comE/comE2 Streptococcus gordonii strain NCTC7865

62.8

100

0.628
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

62.8

100

0.628
  comE/blpR Streptococcus mutans UA159

41.296

98.8

0.408

Multiple sequence alignment