Detailed information NTG1142108

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: DQL01_RS11745
• Genome accession: NZ_LS483451
• Coordinates: 2198320..2199501 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681597.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 4041STDY6836166
• Function: degrading CSP; selective degradation of ComEA and ComEC (predicted from homology) Competence regulation

Genomic Context

Location: 2193320..2204501

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQL01_RS11705	-	2194371..2194913 (+)	543	WP_001158268.1	TetR/AcrR family transcriptional regulator	-
DQL01_RS11720	comE	2195156..2195908 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
DQL01_RS11725	comD/comD2	2195905..2197230 (-)	1326	WP_016397292.1	competence system sensor histidine kinase ComD	Regulator
DQL01_RS11730	comC/comC2	2197251..2197376 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
DQL01_RS11740	rlmH	2197658..2198137 (-)	480	WP_061757162.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQL01_RS11745	htrA	2198320..2199501 (+)	1182	WP_000681597.1	S1C family serine protease	Regulator
DQL01_RS11750	spo0J	2199559..2200317 (+)	759	WP_050087436.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41841.72 Da
• Isoelectric Point: 6.8902

>NTDB_id=1142108 DQL01_RS11745 WP_000681597.1 2198320..2199501(+) (htrA) [Streptococcus pneumoniae strain 4041STDY6836166]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1142108 DQL01_RS11745 WP_000681597.1 2198320..2199501(+) (htrA) [Streptococcus pneumoniae strain 4041STDY6836166]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAAAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus pneumoniae Rx1	100	100	1
htrA	Streptococcus pneumoniae D39	100	100	1
htrA	Streptococcus pneumoniae R6	100	100	1
htrA	Streptococcus pneumoniae TIGR4	100	100	1
htrA	Streptococcus mitis NCTC 12261	97.201	100	0.972
htrA	Streptococcus gordonii str. Challis substr. CH1	66.414	100	0.669
htrA	Streptococcus mutans UA159	54.569	100	0.547