Detailed information NTG1139163

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: DQM54_RS10770
• Genome accession: NZ_LS483375
• Coordinates: 2149310..2150077 (-)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain NCTC3165
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2144310..2155077

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DQM54_RS10750 (NCTC3165_02140)	pth	2147231..2147800 (-)	570	WP_111724267.1	aminoacyl-tRNA hydrolase	-
DQM54_RS10755 (NCTC3165_02141)	ychF	2147873..2148988 (-)	1116	WP_008808030.1	redox-regulated ATPase YchF	-
DQM54_RS10770 (NCTC3165_02144)	comE/comE2	2149310..2150077 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
DQM54_RS10775 (NCTC3165_02145)	comD/comD1	2150074..2151432 (-)	1359	WP_111724324.1	competence system sensor histidine kinase ComD	Regulator
DQM54_RS10780 (NCTC3165_02146)	comC/comC1	2151448..2151612 (-)	165	WP_080998577.1	bacteriocin	Regulator
DQM54_RS10790 (NCTC3165_02148)	rlmH	2151898..2152377 (-)	480	WP_008808034.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
DQM54_RS10795 (NCTC3165_02149)	htrA	2152571..2153764 (+)	1194	WP_111724268.1	S1C family serine protease	Regulator
DQM54_RS10800 (NCTC3165_02150)	spo0J	2153830..2154594 (+)	765	WP_111724269.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=1139163 DQM54_RS10770 WP_008808031.1 2149310..2150077(-) (comE/comE2) [Streptococcus gordonii strain NCTC3165]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=1139163 DQM54_RS10770 WP_008808031.1 2149310..2150077(-) (comE/comE2) [Streptococcus gordonii strain NCTC3165]
ATGAAAGTATTAGTGCTAGAGGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
AAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTGAATCAAC
TCTATTTCTTAGATATAGATATCAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATCCGCCAACATAATCCT
TATGCTATCATTGTTTTTGTTACGAGTCATTCAGAATTTGCGACCTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTCTATAT
ATTGAGACGACAGGAAGCCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTTTATGGGACAATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACATAAGTCATACCTATCTAATATTAGCAACATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTGTATTATGATGGTCATCGTTCACCAATTTCTCGATTACGTGTCAGATACTTG
AAAGAAATACTGAAAGCCAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361