Detailed information NTG1127538

Bioinformatically predicted

Overview

• Name: comE/comE2
• Type: Regulator
• Locus tag: FGL12_RS10870
• Genome accession: NZ_LR594041
• Coordinates: 2218438..2219205 (-)
• Length: 255 a.a.
• NCBI ID: WP_008808031.1
• Uniprot ID: P75031
• Organism: Streptococcus gordonii strain NCTC9124
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2213438..2224205

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
FGL12_RS10850 (NCTC9124_02189)	pth	2216358..2216927 (-)	570	WP_012131076.1	aminoacyl-tRNA hydrolase	-
FGL12_RS10855 (NCTC9124_02190)	ychF	2217001..2218116 (-)	1116	WP_012131077.1	redox-regulated ATPase YchF	-
FGL12_RS10870 (NCTC9124_02193)	comE/comE2	2218438..2219205 (-)	768	WP_008808031.1	competence system response regulator transcription factor ComE	Regulator
FGL12_RS10875 (NCTC9124_02194)	comD/comD1	2219202..2220563 (-)	1362	WP_012131078.1	competence system sensor histidine kinase ComD	Regulator
FGL12_RS10880 (NCTC9124_02195)	comC/comC1	2220579..2220731 (-)	153	WP_012131079.1	bacteriocin	Regulator
FGL12_RS10890 (NCTC9124_02197)	rlmH	2221017..2221496 (-)	480	WP_012131080.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
FGL12_RS10895 (NCTC9124_02198)	htrA	2221690..2222883 (+)	1194	WP_012131081.1	S1C family serine protease	Regulator
FGL12_RS10900 (NCTC9124_02199)	spo0J	2222949..2223713 (+)	765	WP_012131082.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 255 a.a.
• Molecular weight: 30225.48 Da
• Isoelectric Point: 7.0651

>NTDB_id=1127538 FGL12_RS10870 WP_008808031.1 2218438..2219205(-) (comE/comE2) [Streptococcus gordonii strain NCTC9124]
MKVLVLEDTIEHQVRIENVFEEISRELNLEIKAKVTGKIHEFKEYVESDEVNQLYFLDIDIKGEEQKGLEMAQFIRQHNP
YAIIVFVTSHSEFATLTFKYKVSALDFIDKDINDNSFKKRVKDCIVYTRNNLIENTDIVDFFEYSFRGNEIRIPFRDILY
IETTGSPYKLRVVGKNFFKEFYGTIAEIQEQDKELGYFFSPHKSYLSNISNISGYDKKTKDVLYYDGHRSPISRLRVRYL
KEILKAKSKKEENKK

Nucleotide

• Length: 768 bp

>NTDB_id=1127538 FGL12_RS10870 WP_008808031.1 2218438..2219205(-) (comE/comE2) [Streptococcus gordonii strain NCTC9124]
ATGAAAGTATTAGTGCTAGAAGATACTATTGAACATCAAGTGAGAATTGAAAATGTCTTCGAAGAAATTTCTCGCGAACT
TAATCTTGAAATTAAAGCAAAAGTAACAGGAAAAATTCATGAATTTAAAGAATATGTTGAGTCAGACGAGGTAAATCAAC
TTTATTTCTTAGATATAGATATTAAAGGAGAAGAACAAAAAGGTCTAGAAATGGCGCAATTTATACGCCAACATAATCCC
TATGCTATCATTGTTTTTGTCACGAGTCATTCAGAATTTGCGACTTTAACTTTTAAGTATAAAGTATCAGCGTTAGATTT
TATAGATAAAGACATAAATGATAATTCTTTTAAGAAAAGAGTTAAAGATTGCATCGTTTATACACGAAATAATTTAATTG
AAAATACAGATATTGTTGACTTTTTTGAGTATAGTTTTAGAGGAAACGAAATTCGAATTCCTTTTAGAGATATTCTATAT
ATTGAGACGACAGGAAGTCCTTATAAATTAAGAGTTGTTGGAAAAAATTTCTTTAAGGAATTTTATGGGACAATAGCAGA
AATTCAAGAACAAGATAAAGAACTTGGATATTTTTTCTCACCACATAAGTCATACCTATCTAATATTAGCAACATTAGTG
GATACGACAAAAAGACAAAAGATGTTTTATATTATGATGGTCATCGTTCACCGATTTCTCGATTACGTGTCAGATACTTG
AAAGAAATACTGAAAGCCAAAAGTAAAAAAGAAGAAAATAAAAAATAA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

3D structure

• AlphaFold DB: P75031

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/comE2	Streptococcus gordonii strain NCTC7865	100	100	1
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	100	100	1
comE	Streptococcus infantis strain Atu-4	64	98.039	0.627
comE	Streptococcus mitis NCTC 12261	64	98.039	0.627
comE	Streptococcus mitis SK321	63.2	98.039	0.62
comE	Streptococcus pneumoniae Rx1	62.8	98.039	0.616
comE	Streptococcus pneumoniae D39	62.8	98.039	0.616
comE	Streptococcus pneumoniae R6	62.8	98.039	0.616
comE	Streptococcus pneumoniae TIGR4	62.8	98.039	0.616
comE/blpR	Streptococcus mutans UA159	37.551	96.078	0.361